Registration Dossier
Registration Dossier
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EC number: 233-126-1 | CAS number: 10042-59-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Application of a single dermal dose of the test substance to the skin of male and female New Zealand Albino Rabbits for 24 h to determine the acute dermal toxicity.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-propylheptan-1-ol
- EC Number:
- 233-126-1
- EC Name:
- 2-propylheptan-1-ol
- Cas Number:
- 10042-59-8
- Molecular formula:
- C10H22O
- IUPAC Name:
- 2-propylheptan-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Propylheptanol
- Lot/batch No.: NBP 1282594-A
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 1.8 kg, females: 1.9 - 2.0 kg
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 3160, 5010, 7940 mg/kg bw
- No. of animals per sex per dose:
- - 3160 mg/kg: 1 male animal;
- 5010 mg/kg bw: 1 female animal;
- 7940 mg/kg bw: 1 male and 1 female animal; - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - 3160 mg/kg bw: 0/1 (male animal);
- 5010 mg/kg bw: 0/1 (female animal);
- 7940 mg/kg bw: male animal: 1/1; female animal: 0/1;
Deaths occurred on day 2. - Clinical signs:
- other: Increasing weakness, diarrhea, collapse.
- Gross pathology:
- Decedents: Hemorrhagic areas of the lungs, liver and spleen discoloration, enlarged gall bladder, darkened kidneys, and gastrointestinal inflammation;
Survivors: Viscera appeared normal;
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the results of the study a LD 50 value > 5010 mg/kg bw was established under these test conditions. Therefore no classification according to EU or GHS criteria is required.
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