Registration Dossier
Registration Dossier
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EC number: 233-126-1 | CAS number: 10042-59-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically valid.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VI.
- Author:
- Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA
- Year:
- 1 962
- Bibliographic source:
- Industrial Hygiene Journal 23: 95-107
Materials and methods
- Principles of method if other than guideline:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-propylheptan-1-ol
- EC Number:
- 233-126-1
- EC Name:
- 2-propylheptan-1-ol
- Cas Number:
- 10042-59-8
- Molecular formula:
- C10H22O
- IUPAC Name:
- 2-propylheptan-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-propylheptanol
- Analytical purity: not stated
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- other: undiluted sample or solutions in water or propylene glycol
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- SCORING SYSTEM: Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: degree of corneal necrosis
- Time point:
- other: no data available
- Score:
- 2
- Max. score:
- 10
Any other information on results incl. tables
The primary eye irritation was graded as 2.
Applicant's summary and conclusion
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