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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 April 2010 to 02 June 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
Using BS4633: Method for the Determination of Crystallizing Point, designed to be compatible with Method A.1
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994))
Type of method:
method to determine freezing temperature
Key result
Melting / freezing pt.:
< 253 K
Remarks on result:
other: ± 0.5 K
Key result
Melting / freezing pt.:
< -20 °C
Remarks on result:
other: ± 0.5 °c

Table 1: Cooling Data from Determination 1

Time(s)

Temperature (K)

Time(s)

Temperature (K)

Time(s)

Temperature (K)

0

291.55

690

264.55

1380

257.55

30

290.75

720

263.75

1410

257.55

60

289.15

750

263.15

1440

257.35

90

287.35

780

262.15

1470

257.35

120

286.15

810

261.35

1500

257.15

150

284.15

840

261.15

1530

256.95

180

283.15

870

260.75

1560

256.95

210

281.55

900

260.35

1590

256.95

240

280.15

930

259.95

1620

256.55

270

279.15

960

259.55

1650

256.15

300

178.15

990

259.15

1680

255.95

330

276.15

1020

258.95

1710

255.75

360

275.75

1050

258.55

1740

255.35

390

274.55

1080

258.35

1770

255.35

420

273.75

1110

258.15

1800

255.55

450

272.55

1140

258.35

1830

255.95

480

271.35

1170

258.35

1860

256.15

510

270.15

1200

258.35

1890

256.15

540

269.15

1230

258.15

1920

256.15

570

268.15

1260

257.95

1950

256.15

600

267.15

1290

257.75

1980

256.15

630

266.15

1320

257.75

2700*

252.15

660

265.35

1350

257.75

 

 

*No readings were performed between 1980 and 2700 seconds due to the technician and Study Director discussing the test procedure.

Observations: The test material did not change in appearance throughout the test.
Result:
 Freezing temperature <253 K (<-20.0 °C)

Table 2: Cooling Data from Determination 2

Time(s)

Temperature (K)

Time(s)

Temperature (K)

Time(s)

Temperature (K)

0

288.75

690

263.35

1380

256.75

30

287.75

720

262.55

1410

256.15

60

286.95

750

262.15

1440

255.75

90

284.75

780

261.95

1470

255.35

120

283.15

810

261.35

1500

255.15

150

281.35

840

260.95

1530

254.95

180

280.15

870

260.35

1560

254.75

210

279.15

900

259.95

1590

254.35

240

277.95

930

259.75

1620

254.15

270

276.55

960

259.15

1650

253.75

300

275.55

990

258.95

1680

253.35

330

274.15

1020

258.55

1710

253.35

360

272.75

1050

258.15

1740

253.35

390

271.55

1080

257.95

1770

253.15

420

270.35

1110

257.55

1800

252.95

450

269.15

1140

257.35

1830

252.55

480

268.35

1170

257.55

1860

252.35

510

267.35

1200

257.75

1890

252.35

540

266.35

1230

257.75

1920

252.15

570

265.95

1260

257.75

 

 

600

265.35

1290

257.55

 

 

630

264.55

1320

257.55

 

 

660

263.95

1350

257.15

 

 

Observations: The test material did not change in appearance throughout the test.
Result:
 Freezing temperature <253 K (<-20.0 °C)

Conclusions:
The freezing temperature of the the test material has been determined to be less than 253 ± 0.5 K (less than -20.0 ± 0.5 °C).
Executive summary:

In a GLP study conducted to a BS4633: Method for the Determination of Crystallizing Point, designed to be compatible with EU Method A.1, the freezing point of the test material was determined.

Under the conditions of this study, the freezing point of the test material was recorded to be less than 253 K (± 0.5 K), less than 20 °C (± 0.5 °C).

Description of key information

In a GLP study conducted to a BS4633: Method for the Determination of Crystallizing Point, designed to be compatible with EU Method A.1, the freezing point of the test material was determined. The freezing point of the test material was recorded to be less than 253 K (± 0.5 K), less than -20 °C (± 0.5 °C).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-20 °C

Additional information

Butler RE & White DF (2010) was selected as the key study for this data requirementas the study was performed to a method designed to be compatible with EU method A.1, and was GLP compliant. The study was considered of high reliability and therefore suitable as a stand alone study. A reliability rating of 1 was assigned to this study, according to the criteria of Klimisch, 1997

Supporting information is also available from a material safety data sheet, Atofina Chemicals Inc. (2001).

A reliability rating of 4 was assigned to this study, according to the criteria of Klimisch, 1997 as this information is from a secondary source.

Result: - 18 °C (no pressure reported)