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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 April 2010 to 02 June 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
With the exception of the calculation of boiling temperature, the study was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
Type of method:
other: liquid bath at atmospheric pressure, designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC)
Key result
Boiling pt.:
547 K
Atm. press.:
102.31 kPa
Decomposition:
yes
Decomp. temp.:
506 K

Table 1: Determination 1

T (K)

Observations

294

Clear colourless liquid

506

The test material became pale yellow.

508

The test material remained a pale yellow liquid with pale yellow precipitate forming at the bottom of the tube.

529

The test material remained a pale yellow liquid with pale yellow precipitate forming at the bottom of the tube.

Result: Decomposition from 506 K

Table 2: Determination 2

T (K)

Observations

308

Clear colourless liquid

509

The test material became cloudy and pale yellow.

511

The test material remained a cloudy pale yellow liquid with pale yellow precipitate forming at the bottom of the tube.

Result: Decomposition from 509 K

Atmospheric pressure: 102.31 kPa

Conclusions:
The test material was determined to decompose at approximately 506 K (233 °C) at 102.31 kPa. As a result, no boiling point could be determined experimentally. A calculated boiling point was obtained using specialist computer estimation software (Adapted Stein & Brown method, MPBPVP v1.43 (September 2008) ©2000 U.S. Environmental Protection Agency). The calculated boiling point of the the test material was 547 K (274 °C).
Executive summary:

The test material was found to decompose from approximately 506 K (233 °C) at 102.31 kPa using liquid bath apparatus designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008. As a result of this, no value for boiling temperature could be determined. A calculated value of boiling temperature gave a result of 547 K (274 °C).

 

Description of key information

The test material was found to decompose from approximately 506 K (233 °C) at 102.31 kPa using liquid bath apparatus designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008. As a result of this, no value for boiling temperature could be determined. A calculated value of boiling temperature gave a result of 547 K (274 °C).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
547 K

Additional information

Butler and White (2010) was selected as the key study for this endpoint as the experimental portion of the study was performed to GLP and using an appropriate method for the test material designed to be compatible with the internationally accepted guideline EU Method A.1. A reliability rating of 1 was assigned to this study, according to the criteria of Klimisch, 1997.

Supporting studies also available:

For the Jones et al (1947) study a reliability rating of 4 was assigned to this study, according to the criteria of Klimisch, 1997 as only the endpoint results was available and no method was specified.

The boiling point for the test material was reported as 290 °C.

For the ATSDR (2005) report a reliability rating of 4 was assigned to this study, according to the criteria of Klimisch, 1997 as this information is from a secondary source.

The boiling point for the test material is given as between 145-147 °C at 5 mm Hg.

Supporting information is also available from a Tributyltin chloride material safety data sheet, Atofina Chemicals Inc. (2001).

A reliability rating of 4 was assigned to this study, according to the criteria of Klimisch, 1997 as this information is from a secondary source.

The boiling point for the test material is given as 290 °C. The pressure of the study was not reported.