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EC number: 215-958-7 | CAS number: 1461-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
A supporting study for repeated dose inhalation is avaialable. The LOAEL in female rats exposed to the test material was determined to be 3 ppm in a 95 day inhalation study. Effects noted were; inflammatory changes consisting of hyperaemia and bronchitis observed in the respiratory system. Fatty degeneration was also observed at necropsy in animals killed after the exposure period. Inflamed eyes and nasal mucous membranes were observed in the last month of the study.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not specified
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method not reported.
Reference: Gohlke VR, Lewa W, Strachovsky A, et al. 1969. [Animal experimental studies on the inhalatory effects of tributyltin chloride in a subchronic test.] Gezamte Hyg 15:97-104. (German) - GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: No data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- The animals were exposed to concentrations of 4–6 mg/m^3 (0.30–0.45 ppm) for 6 hours/day, 5 days/week for 95 days
- Frequency of treatment:
- 6 hours/day, 5 days/week.
- Dose / conc.:
- 4 mg/m³ air
- Remarks:
- 4-6 mg/m^3
- Dose / conc.:
- 6 mg/m³ air
- Remarks:
- 4-6 mg/m^3
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Inflamed eyes and nasal mucous membranes were observed in the last month of a 95-day inhalation study of the test material in female rats.
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Inflammatory changes consisting of hyperaemia and bronchitis were observed in the respiratory system.
Fatty degeneration was observed at necropsy in animals killed after a 95-day exposure period. - Dose descriptor:
- LOAEC
- Effect level:
- 3 ppm
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Respiratory, hepatic & ocular effects
- Critical effects observed:
- not specified
- Conclusions:
- The LOAEL in female rats exposed to the test material was determined to be 3 ppm.
- Executive summary:
The LOAEL in female rats exposed to the test material was determined to be 3 ppm.
Effects noted were inflammatory changes consisting of hyperaemia and bronchitis which were observed in the respiratory system.
Fatty degeneration was observed at necropsy in animals killed after a 95-day exposure period. Inflamed eyes and nasal mucous membranes were observed in the last month of a 95-day inhalation study of tributyltin chloride in female rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is a supporting study for repeated dose inhalation:
For the ASTDR (2005) report a reliability rating of 4 was assigned to this study, according to the criteria of Klimisch, 1997 as this information is from a secondary source. The LOAEL in female rats exposed to the test material was determined to be 3 ppm in a 95 day inhalation study. Effects noted were; inflammatory changes consisting of hyperaemia and bronchitis observed in the respiratory system. Fatty degeneration was also observed at necropsy in animals killed after the exposure period. Inflamed eyes and nasal mucous membranes were observed in the last month of the study.
Justification for classification or non-classification
It should be noted that although there are no reliable data available for repated dose endpoints, as they are not needed for intermediate substances, the results from the supporting inhalation study would suggest that classification for these endpoints should be considered.
With this in mind, it should be noted that the official classification for tributyltin compounds according to regulation (EC) No 1272/2008, Annex VI, Table 3.1 are as follows:
Classification | Labelling | ||
Hazard class and category code(s) | Hazard statement code(s) | Pictogram signal word code(s) | Hazard statement code(s) |
Acute Tox. 3* | H301 | H301 | |
Acute Tox. 4* | H312 | H312 | |
STOT RE 1 | H372** | GHS06 | H372** |
Eye Irrit. 2 | H319 | GHS08 | H319 |
Skin Irrit. 2 | H315 | GHS09 | H315 |
Aquatic Acute 1 | H400 | Dgr | H410 |
Aquatic Chronic 1 | H410 |
Specific concentration limits and M factors | |
Concentration | Classification |
* | - |
STOT RE 1; H372 | C ≥ 1 % |
STOT RE 2; H373 | 0,25 % ≤ C < 1 % |
Skin Irrit. 2; C ≥ 1 % | - |
Eye Irrit. 2; C ≥ 1 % | - |
M = 10 | - |
Therefore the classification for this endpoint will be STOT RE1; H372: Causes damage to organs through prolonged or repeated exposure, according to regulation (EC) No 1272/2008. No details of specific organs as data taken from Annex VI classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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