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Registration Dossier
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EC number: 203-438-2 | CAS number: 106-88-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given, comparable to guideline/standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- dynamic inhalation method with analytical and nominal determination of the concentration.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- purity: 99.9%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight of the animals: 185 +/- 15 g. Standard diet and tap water ad libitum during the observation period.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- ANALYTICAL EXAMINATIONS:
1. Apparatus, chemicals and solutions:
- gaschromatograph HP 5840 A
- dimethylformamid
2. Sampling:
- apparatus: 2 consecutive connected absorption vessels and a downstream fritted bottle
- sorption agent: dimethylformamide
- sampling rate: 1 liter/min
- sampling amount: 3 liter
- sampling place: near the animals' nose
- sampling probe: diameter 4 mm
3. Analytical determination method:
- gaschromatographically
- principle of the method: n-butylenoxide was determined in dimethylformamide
Supplying of the test substance with a prolonged infusion pump in a constant volume on a 93°C heated evaporator; the refined vapours were mixed with a fresh air flow and were conducted through an inhalation chamber with a chamber content of about 200 liters. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 6.3 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- Dynamic inhalation test with analytical monitoring; post exposure observation period: 14 days
As a first orientating dose, a concentration was used which allow a classification in a toxic class. A dose level ought to allow an no effect level (no mortality).
The inhalation mixture was offered for 4 hours.
The body weight of the animals were checked before starting of the study, after 7 days and at the end of the observation period. Clincal signs and mortality were checked daily.
After the 14-day observation period the animals were killed and a pathological-anatomical evaluation was done. - Statistics:
- none
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6.3 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortalities.
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 25 mg/L air (analytical)
- Exp. duration:
- 1 h
- Remarks on result:
- other: No mortalities.
- Mortality:
- none
- Clinical signs:
- other: no symptoms
- Gross pathology:
- nothing abnormal detected
Any other information on results incl. tables
Absolute body weight growth:
Mean body weight | before starting | after 7 days | after 14 days | |||
males | females | males | females | males | females | |
Group 1 |
||||||
Body weight in g | 185 | 178 | 219 | 190 | 258 | 206 |
No. of animals | 10 | 10 | 10 | 10 | 10 | 10 |
Control | ||||||
Body weight in g | 178 | 180 | 219 | 190 | 254 | 210 |
No. of animals | 10 | 10 | 10 | 10 | 10 | 10 |
Relative body weight growth:
Mean body weight | before starting | after 7 days | after 14 days | |||
males | females | males | females | males | females | |
Group 1 |
||||||
Body weight in g | 0 | 0 | 34 | 12 | 73 | 28 |
No. of animals | 10 | 10 | 10 | 10 | 10 | 10 |
Control | ||||||
Body weight in g | 0 | 0 | 41 | 10 | 76 | 30 |
No. of animals | 10 | 10 | 10 | 10 | 10 | 10 |
No significant differences regarding body weight growth in comparison to the air control group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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