1,2-epoxybutane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

dynamic inhalation method with analytical and nominal determination of the concentration.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,2-epoxybutane

EC Number:

203-438-2

EC Name:

1,2-epoxybutane

Cas Number:

106-88-7

Molecular formula:

C4H8O

IUPAC Name:

oxolane

Test material form:

liquid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: WIGA Sulzfeld, Germany
- Age at study initiation: no data
- Weight at study initiation: 185 +/- 15 g
- Housing: no data
- Diet: ad libitum, Standard diet
- Water: ad libitum
- Acclimation period: no data

Administration / exposure

Route of administration:

inhalation: vapour

Vehicle:

other: unchanged (no vehicle)

No. of animals per sex per dose:

10

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The body weight of the animals were checked before starting of the study, after 7 days and at the end of the observation period. Clinical signs and mortality were checked daily.
- Necropsy of survivors performed: yes; After the 14-day observation period the animals were killed and a pathological-anatomical evaluation was done.

Statistics:

none

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 6.3 mg/L air (analytical)

Mortality:

none

Clinical signs:

other: no symptoms

Body weight:

No significant differences regarding body weight growth in comparison to the air control group (see table)

Gross pathology:

nothing abnormal detected

Any other information on results incl. tables

Absolute body weight growth:

Mean body weight	before starting		after 7 days		after 14 days
	males	females	males	females	males	females
Group 1
Body weight in g	185	178	219	190	258	206
No. of animals	10	10	10	10	10	10
Control
Body weight in g	178	180	219	190	254	210
No. of animals	10	10	10	10	10	10

 

Relative body weight growth:

Mean body weight	before starting		after 7 days		after 14 days
	males	females	males	females	males	females
Group 1
Body weight in g	0	0	34	12	73	28
No. of animals	10	10	10	10	10	10
Control
Body weight in g	0	0	41	10	76	30
No. of animals	10	10	10	10	10	10

 

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met