Registration Dossier
Registration Dossier
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EC number: 203-438-2 | CAS number: 106-88-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
In a skin irritation test according to the method of Draize, the test substance was found to be non-irritating after 4 hours for rabbits (BASF, 1981). The test substance was given unchanged (semiocclusive conditions) to the shaved skin.
Another skin irritation test following earlier BASF-internal guidelines (rabbits; BASF, 1979) found a corrosive potential after 1-hour exposure under occlusive conditions (unchanged test substance).
In an older BASF study (1975; internal guidelines) skin irritation was found after 20-hour exposure (rabbits; unchanged test substance; occlusive conditions).
DOW (1965) reported no skin irritation when administered the undiluted test material to the intact and abraded skin of rabbits. It was concluded, that prolonged contact might burn the abraded skin.
No skin irritation was found for rabbits when administered undiluted 2-ethyloxirane to the clipped skin and uncovered under open conditions (DOW, 1958).
In an older study (DOW, 1953) it was concluded that the test substance is severely irritating to the skin of rabbits upon prolonged exposure. A single prolonged contact with the undiluted test substance will cause blistering and necrosis. Prolonged and repeated contact with solutions of the order of 1% may cause severe irritation and superficial necrosis. A single short exposure should cause no reactions.
BASF (1975) found an eye irritation potential for rabbits when tested with BASF-internal guidelines. The test substance was given unchanged into the eye for 20 hours.
DOW (1958) reported that rabbit eyes were moderately burned by 0.005 ml of the undiluted test substance while 0.02 ml caused marked eye damage.
In an older DOW study (1953) it was concluded that the test substance is moderately irritating to the eyes of rabbits. Undiluted butylene oxide presents a definite hazard of eye injury. Pain and conjunctival inflammation may persist for several days. Transient corneal injury may occur, but is expected to heal completely within a few days. Weak solutions (1% or less) are not irritating to the eyes of rabbits.
Effect level: empty Endpoint conclusion: Adverse effect observed
Effect level: empty Endpoint conclusion: Adverse effect observed
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
The test substance is classified according to Annex I to the Directive 67/548/EEC with R 36/37/38 (Xi).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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