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Registration Dossier
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EC number: 203-438-2 | CAS number: 106-88-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 953
- Report date:
- 1953
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Test material was administered to the eyes of 4 rabbits to investigate irritative properties.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-epoxybutane
- EC Number:
- 203-438-2
- EC Name:
- 1,2-epoxybutane
- Cas Number:
- 106-88-7
- Molecular formula:
- C4H8O
- IUPAC Name:
- oxolane
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- other: Undiluted and 1% in propylene glycol
- Controls:
- no
- Amount / concentration applied:
- Administered undiluted and as 1% in propylene glycol.
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- 4 rabbits
- Details on study design:
- Undiluted test material was administered to the eye of a rabbit and left unwashed. Undiliuted test material was also administered to the eye of a rabbit and then the eye was washed with water.
The test material was administered as 1% in propylene glycol to the eye of a rabbit and left unwashed. The 1% in propylene glycol was also administered to the eye of a rabbit and then the eye was washed with water.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- overall irritation score
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Undiluted test material- unwashed: moderate conjunctivitis and corneal necrosis
Undiliuted test material- washed: slight conjunctivitis and corneal necrosis
1% in propylene glycol- unwashed: slight pain and questionable irritation
1% in propylene glycol- washed: no significant response
Any other information on results incl. tables
Butylene Oxide is moderately irritating to the eyes. Undiluted butylene oxide presents a definite hazard of eye injury. Pain and conjunctival inflammation may persist for several days. Transient corneal injury may occur, but is expected to heal completely within a few days. Weak solutions (1% or less) are not irritating to the eye.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
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