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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Test material was administered to the eyes of 4 rabbits to investigate irritative properties.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-epoxybutane
EC Number:
203-438-2
EC Name:
1,2-epoxybutane
Cas Number:
106-88-7
Molecular formula:
C4H8O
IUPAC Name:
oxolane
Test material form:
liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
other: Undiluted and 1% in propylene glycol
Controls:
no
Amount / concentration applied:
Administered undiluted and as 1% in propylene glycol.
Duration of treatment / exposure:
No data
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
4 rabbits
Details on study design:
Undiluted test material was administered to the eye of a rabbit and left unwashed. Undiliuted test material was also administered to the eye of a rabbit and then the eye was washed with water.

The test material was administered as 1% in propylene glycol to the eye of a rabbit and left unwashed. The 1% in propylene glycol was also administered to the eye of a rabbit and then the eye was washed with water.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
not determinable
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
not determinable
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
not determinable
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
not determinable
Irritation parameter:
overall irritation score
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Undiluted test material- unwashed: moderate conjunctivitis and corneal necrosis
Undiliuted test material- washed: slight conjunctivitis and corneal necrosis

1% in propylene glycol- unwashed: slight pain and questionable irritation
1% in propylene glycol- washed: no significant response

Any other information on results incl. tables

Butylene Oxide is moderately irritating to the eyes. Undiluted butylene oxide presents a definite hazard of eye injury. Pain and conjunctival inflammation may persist for several days. Transient corneal injury may occur, but is expected to heal completely within a few days. Weak solutions (1% or less) are not irritating to the eye.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification