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Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

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Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Test substance stable:
no
Transformation products:
yes

In alcohol, urethanes were formed by isocyanates.

Executive summary:

Isocyanates form urethanes in alcohol (Beyer, 2004)

Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: "in house" method "Determination of the NCO-content by capillary GC-chromatography".
GLP compliance:
yes
Test substance stable:
yes
Transformation products:
not measured

The concentration of the test substance in the acetonitrile solution without addition of water was stable over the measurement time (at least 6 hours) at room temperature.

Executive summary:

The concentration of the test substance in the acetonitrile solution without addition of water was stable over at least 2 hours at room temperature (Bayer AG, 1999).

Description of key information

In protic solvents like alcohols, isocyanates react rapidly. Stablility is expected with non-protic solvents like toluene, acetone, dioxane etc. Isocyanates form urethanes in alcohol. The concentration of 4,4’-methylenedicyclohexyl diisocyanate in an acetonitrile solution without addition of water was stable over at least 6 hours at room temperature.

Additional information

Reference:

Bayer AG, 1999

Guideline:

"in house" method "Determination of the NCO-content by capillary GC-chromatography"