Registration Dossier
Registration Dossier
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EC number: 203-870-1 | CAS number: 111-44-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from assessment report, no study details were provided.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- Agency for Toxic Substances and Disease Registry, U. S. Public Health Services
- Year:
- 1 989
- Bibliographic source:
- http://www.atsdr.cdc.gov/toxprofiles/tp127.pdf
Materials and methods
- Principles of method if other than guideline:
- no information
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-chloroethyl) ether
- EC Number:
- 203-870-1
- EC Name:
- Bis(2-chloroethyl) ether
- Cas Number:
- 111-44-4
- Molecular formula:
- C4H8Cl2O
- IUPAC Name:
- 1-chloro-2-(2-chloroethoxy)ethane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 250 ppm
- Exp. duration:
- 4 h
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 1 462 mg/m³ air
- Exp. duration:
- 4 h
- Remarks on result:
- other: mg/m³ calculated as mg/m³ = ppm *(MW/24.45)=ppm*(143.01/24.45)=250*143.01/24.45=1462 mg/m³
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 4 h LD50 inhalation is about 1.46 mg/L (250 ppm)
- Executive summary:
"Exposure of rats to 250 ppm for 4 hours caused death in about half the animals (Carpenter et al. 1949)." (cited in ATSDR 1989, page 14)
This is equivalent to 1.462 mg/L.
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