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Carcinogenicity

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Description of key information

From animal tests there is evidence that BCEE has a cancerogenic potential. 

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Additional information

The ATSDR report concludes:

"The principal reason for concern with BCEE is its apparent carcinogenic potential. The most direct evidence indicating that BCEE is carcinogenic is the increased incidence of hepatomas in two strains of mice dosed orally for 80 weeks (Innes et al. 1969). This is supported by limited data indicating that BCEE is mutagenic in some bacterial test systems, although several studies have yielded negative results. On the other hand, increased incidence of mouse liver hepatomas has been questioned as a reliable indication of true carcinogenic potential (Maronpot et al. 1987), and BCEE was not observed to cause a significant increase in tumors in a chronic feeding study in rats (Weisburger et al. 1981) or in parenteral exposure studies in mice (Theiss et al. 1977; Van Duuren et al. 1972) and rats (Norpoth et al. 1986). Also, no binding of BCEE to DNA and no foci of ATPase-deficient cells (a sign of pre-neoplastic effects) were detected in liver of rats exposed to BCEE (Gwinner et al. 1983), and no evidence of heritable chromosome damage was detected in a preliminary study in mice (Jorgenson et al. 1978). Consequently, while the positive carcinogenicity findings in mice are adequate to conclude that BCEE may be a human carcinogen,the evidence on this point is limited."