Registration Dossier
Registration Dossier
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EC number: 910-757-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Non-GLP studies similar to OECD guideline 404 and 405 are available for DVB-55 and DVB-HP. In addition a published summary of an eye irritation study conducted with an unknown grade of the reaction mass is available.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Both skin irritation studies on DVB-55 and DVB-HP used repeated exposures (4 -10 applications) of the test material. Twenty-four hours after the first application only little irritation was seen. Prolonged or repeated skin contact with the test material on unconfined rabbit skin resulted in slight redness, slight swelling, slight exfoliation, and, after 10 applications, a moderate burn which resulted in scar formation. Contact on confined skin resulted in marked redness, slight to moderate swelling, moderate exfoliation, and, after 4 applications, a moderate burn which resulted in scar formation.
Instillation of DVB-HP into the eyes of a rabbit resulted in slight discomfort and transient very slight conjunctival redness. All signs of eye irritation were essentially absent by 1 hour post-exposure. Very slight signs of eye irritation observed after this time were felt to be spontaneous in nature and unrelated to application of the test material. Only slight effects on the conjunctivae were observed after the instillation of DVB-55 into the eyes of rabbits. No effects on the cornea and internal structures of the eye were observed and all effects were reversible within the observation period.
The grades tested cover the highest concentration of divinylbenzene (DVB-HP: 80% divinylbenzene and 20% ethylstyrene) and ethylstyrene (DVB-55: 55% divinylbenzene and 45% ethylstyrene).
No experimental data on respiratory irritation is available for any grade of DVB/EVB.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the slight irritation after a single application of different grades of the reaction mass, a classification as "skin irritant" is recommended for all grades of the reaction mass of divinylbenzene and ethylstyrene.
Only slight effects on the conjunctivae were observed after the instillation of different grades of the reaction mass into the eyes of rabbits. No effects on the cornea and internal structures of the eye were observed and all effects were resersible within the observation period. As no scores according to EU criteria have been reported in the study for DVB-55 it is unclear whether the criteria for classification are met or not. Hence, a precautionary classification as "eye irritant" is recommended for all grades of the reaction mass of divinylbenzene and ethylstyrene.
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