Itaconic acid

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Report date:

1983

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Itaconic acid

EC Number:

202-599-6

EC Name:

Itaconic acid

Cas Number:

97-65-4

Molecular formula:

C5H6O4

IUPAC Name:

2-methylidenebutanedioic acid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Type of coverage:

not specified

Vehicle:

other: gum arabic

Duration of exposure:

15 day

Doses:

2000 mg/kg bodyweight

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

A group of ten rats 5 males and 5 females was given a single dermal application of itaconic acid formulated in gum arabic, at a dose level of 2000 mg/kg bodyweight. All surviving animals were sacrificed and examined macroscopically on day 15, the end of the observation period.

Results and discussion

Effect levels

Dose descriptor:

LD0

Effect level:

> 2 000 mg/kg bw

Mortality:

no

Any other information on results incl. tables

There were no death and no sign of systemic reaction to treatment. Bodyweight gains were normal and no abnormalities were recorded at the macroscopic examination on day 15.