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EC number: 204-617-8 | CAS number: 123-31-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
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- Genetic toxicity
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- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of hydroquinone to Daphnia magna was investigated in a study conducted equivalent or similar to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) under semi-static conditions and under GLP. A 48 h EC50=0.134 mg/L based on measured initial concentration was determined.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.134 mg/L
Additional information
Four studies dealing with the acute toxicity of hydroquinone to Daphnia are available; three studies with an exposure period of 48 hours and one study with 24 hours. The EC50 nvalues of the 48 hour tests ranged from 0.13 to 0.29 mg/L based on nominal or measured initial concentrations.
Only in one study the acute toxicity of hydroquinone to Daphnia magna was investigated equivalent to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) under semi-static conditions and under GLP. The daphnids (20 animals/concentration) were exposed to measured concentration of 0 (control), 0.029, 0.043, 0.074, 0.11, and 0.18 mg/L for 48 h. The test substance concentrations were measured by HPLC/UV. The endpoint examined was immobilization. The 48 h NOEC, EC50, and EC100 were determined to be 0.029, 0.061, and 0.11 mg/L based on mean measured concentrations. As it has not been possible to discriminate between the effect of hydroquinone and its oxidation products the initial concentration is regarded as relevant concentration.
Therefore, the daphnia test is re-evaluated based on the measured initial concentration. Thus, a 48 h EC50=0.134 mg/L (recalculated measured initial concentration) has to be taken into account for assessment. The testing/validity criteria laid down in the OECD guideline 202 are fulfilled. These findings are supported by a study conducted according to ISO 6341 15 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea)) and in a study conducted according to DIN 38412, Part II 'Daphnia short-time test' (comparable to OECD Guideline 202 'Daphnia sp. Acute Immobilisation Test'). The 48 h EC50 values were found to be 0.13 mg/L nominal (ISO 6341 15; mean of two tests) and 0.29 mg/L nominal (DIN 38412, Part II). The very high acute toxicity of hydroquinone to Daphnia magna (24 h LC50=0.09 mg/L nominal) found in a study conducted comparable to the German DIN 38412, Part II in 1977 could not be confirmed in the aforementioned guideline studies.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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