2-(2-ethoxyethoxy)ethyl acetate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

other: Standard Methods for the Examination of Water and Wastewater, 13th Edition, 1971

GLP compliance:

not specified

Analytical monitoring:

no

Vehicle:

no

Details on test solutions:

PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test substance was directly added to the dilution water.

Test organisms (species):

Pimephales promelas

Details on test organisms:

TEST ORGANISM
- Common name: fathead minnow
- Source: Obtained from commercial suppliers.
- Length at study initiation: 2.5 - 5.0 cm

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Hardness:

30 - 60 mg/L

Test temperature:

71 - 76 °F (21.6 - 24.4 °C)

pH:

7.1 (initial)

Dissolved oxygen:

7.5 - 9.0 mg/L

Details on test conditions:

TEST SYSTEM
- Test vessel:
- Fill volume: 18.5 L
- Aeration: yes
- No. of organisms per vessel: 10

EFFECT PARAMETERS MEASURED: mortality

TEST CONCENTRATIONS
- Range finding study
- Test concentrations: Concentrations ranging from 10 - 10000 mg/L to identify definite test concentrations.

Reference substance (positive control):

not specified

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

125 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

110 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

110 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Description of key information

LC50 (96 h): 110 mg/L for Pimephales promelas (Standard Methods for the Examination of Water and Wastewater (13th Edition, 1971))

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

LC50

Effect concentration:

110 mg/L

Additional information

One study investigating the short-term toxicity of 2-(2-ethoxyethoxy)ethyl acetate (CAS 112-15-2) to fish is available (Waggy & Payne, 1974). The study was performed according to the Standard Methods for the Examination of Water and Wastewater (13th Edition, 1971) under non-GLP conditions. Pimephales promelas was exposed to concentrations of 10 - 10000 mg/L (nominal). After the exposure of 96 h an LC50 of 110 mg/L was calculated.