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Diss Factsheets

Administrative data

Endpoint:
fish early-life stage toxicity
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1995 (prolonged), 2004 (ELS)
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study, only results are published, study report not available

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
p-toluidine
EC Number:
203-403-1
EC Name:
p-toluidine
Cas Number:
106-49-0
Molecular formula:
C7H9N
IUPAC Name:
p-toluidine
Details on test material:
- Name of test material (as cited in study report): p-Toluidine
- Analytical purity: no data

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Oryzias latipes

Study design

Water media type:
freshwater

Results and discussion

Effect concentrationsopen allclose all
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
85 mg/L
Remarks on result:
other: prolonged test, according to OECD TG 204
Duration:
21 d
Dose descriptor:
LC50
Effect conc.:
80 mg/L
Remarks on result:
other: prologned test, according to OECD TG 204
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
13 mg/L
Remarks on result:
other: prolonged test, according to OECD TG 204
Dose descriptor:
LOEC
Effect conc.:
1.2 mg/L
Remarks on result:
other: chronic test - ELS, according to OECD TG 210
Dose descriptor:
NOEC
Effect conc.:
0.6 mg/L
Remarks on result:
other: chronic test ELS, according to OECD TG 210

Applicant's summary and conclusion