Registration Dossier
Registration Dossier
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EC number: 203-403-1 | CAS number: 106-49-0
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1995 (prolonged), 2004 (ELS)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study, only results are published, study report not available
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- p-toluidine
- EC Number:
- 203-403-1
- EC Name:
- p-toluidine
- Cas Number:
- 106-49-0
- Molecular formula:
- C7H9N
- IUPAC Name:
- 4-methylaniline
- Details on test material:
- - Name of test material (as cited in study report): p-Toluidine
- Analytical purity: no data
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Oryzias latipes
Study design
- Water media type:
- freshwater
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 85 mg/L
- Remarks on result:
- other: prolonged test, according to OECD TG 204
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- 80 mg/L
- Remarks on result:
- other: prologned test, according to OECD TG 204
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 13 mg/L
- Remarks on result:
- other: prolonged test, according to OECD TG 204
- Dose descriptor:
- LOEC
- Effect conc.:
- 1.2 mg/L
- Remarks on result:
- other: chronic test - ELS, according to OECD TG 210
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.6 mg/L
- Remarks on result:
- other: chronic test ELS, according to OECD TG 210
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
