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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Remarks:
G-013
Type of method:
flask method
Water solubility:
34.55 g/L
Temp.:
20 °C
pH:
5.4
Remarks on result:
other: in distilled water
Water solubility:
15.68 g/L
Temp.:
20 °C
pH:
4
Remarks on result:
other: in buffer solution
Water solubility:
18.02 g/L
Temp.:
20 °C
pH:
7
Remarks on result:
other: in buffer solution
Water solubility:
28.45 g/L
Temp.:
20 °C
pH:
10
Remarks on result:
other: in buffer solution

Solubility of the Chelat Fe(III) HBED in water for pH 5.4; flask method

 

 

Results of the preliminary test

                     0.1g in x mL of solution

Result

 

0.1

 

0.5

 

1

 

2

 

10

 

100

 

> 100

Soluble (+/-)

-

-

-

-

+

 

 

Approximate solubility, [g/L]

> 1000

200

to 1000

100 to 200

50

to 100

10

to

50

1

to

10

< 1

x – distilled water.

 

 

Solubility results Chelat Fe(III) HBED in water for pH 5.4

Mixing time [hours]

72

118

142

1 flask

Concentration Chelat Fe(III) HBED, [g/L]

34.31

34.48

35.23

pH

7.40

7.41

7.40

2 flask

Concentration Chelat Fe(III) HBED, [g/L]

34.23

34.71

34.07

pH

7.43

7.41

7.43

3 flask

Concentration Chelat Fe(III) HBED, [g/L]

34.28

34.46

35.23

pH

7.40

7.43

7.43

Average concentration Chelat Fe(III) HBED, [g/L]

34.27

34.55

34.84

Temperature [°C]

20.03

20.03

20.03

 

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
Water solubility of test substance as a function of pH at 20 ±0.5°C:
34.55 g/L with distilled water at pH 5.4;
15.68 g/L with buffer solution at pH 4.0;
18.02 g/L with buffer solution at pH 7.0;
28.45 g/L with buffer solution at pH 10.0.
Executive summary:

The water solubility of the test substance was determined in a GLP study (2009) according to EU method A.6 by using the flask method. At 20°C following results for the water solubility as a function of pH have been obtained:

34.55 g/L with distilled water at pH 5.4;

15.68 g/L with buffer solution at pH 4.0;

18.02 g/L with buffer solution at pH 7.0;

28.45 g/L with buffer solution at pH 10.0.

Description of key information

The water solubility of the test substance was determined in a GLP study (2009) according to EU method A.6 by using the flask method. At 20°C following results for the water solubility as a function of pH have been obtained:
34.55 g/L with distilled water at pH 5.4;
15.68 g/L with buffer solution at pH 4.0;
18.02 g/L with buffer solution at pH 7.0;
28.45 g/L with buffer solution at pH 10.0.

Key value for chemical safety assessment

Water solubility:
34 550 mg/L
at the temperature of:
20 °C

Additional information