2-methoxy-1-methylethyl acetate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1996-1997

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: There are no guidelines for this type of occupational exposure study and there is sufficient information to permit a meaningful evalaution of study results

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Biological monitoring of occupational exposure to 1-methoxy-2- propanol

Author:

Laitinen J. et al

Year:

1997

Bibliographic source:

Journal of Chromatography B, 694 (1), (1997) 93-98

Materials and methods

Type of study / information:

Type of experience: Human

Endpoint addressed:

not applicable

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

At the end of a workweek 23 silkscreen printers gave a urine sample for capillary gas chromatographic analysis for 1,2-propanediol

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-methoxy-1-methylethyl acetate

EC Number:

203-603-9

EC Name:

2-methoxy-1-methylethyl acetate

Cas Number:

108-65-6

Molecular formula:

C6H12O3

IUPAC Name:

2-methoxy-1-methylethyl acetate

Method

Ethical approval:

not specified

Details on study design:

The study was conducted at the end of a workweek. Silkscreen printers (n523) inhalation exposure to 1-methoxy-2-propanol, 1-ethoxy-2-propanol and their acetates was measured from the breathing zone during an 8-h workshift. Healthy clerks (n=14) and fire fighter cadets (n=27) served as unexposed controls, and they also gave urine samples on Friday afternoon at the end of the workshift. None of the controls had a health problem. The statistical differences in the excretion between the controls and the exposed subjects were evaluated with the Student t-test.

Exposure assessment:

not specified

Details on exposure:

same as above

Results and discussion

Results:

At the end of a workweek 23 silkscreen printers gave a urine sample for capillary gas chromatographic analysis for 1,2-propanediol. The mean concentration was 2.52 (S.D. 2.01) mmol mol creatinine-1 (median=1.76,  n=23). The urinary excretion of 1,2-propanediol was linearly dependent on  the preceding 1-methoxy-2-propanol exposure measured in the worker's breathing zone (y=0.99+0.28x, n=23, r=0.67, where y is the urinary 1,2-propanediol concentration, in mmol mol creatinine-1 and x is the concentration, in cm3 m-3, of 1-methoxy-2-propanol (90.2%),  1-ethoxy-2-propyl acetate (5.8%), PMA (2.1%) and 1-ethoxy-2-propanol  (1.9%) in the air).

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:

In conclusion, biological monitoring of 1-alkoxy-propanol exposure is possible by urinalysis for its metabolite 1,2-propanediol. At very low occupational exposure levels, the results may be confounded by background excretion of 1,2-propanediol originating from e.g., consumer cosmetics.

Executive summary:

At the end of a workweek 23 silkscreen printers gave a urine sample for capillary gas chromatographic analysis for 1,2-propanediol. The mean concentration was 2.52 (S.D. 2.01) mmol mol creatinine-1 (median=1.76,  n=23). The urinary excretion of 1,2 -propanediol was linearly dependent on  the preceding 1-methoxy-2-propanol exposure measured in the worker's breathing zone (y=0.99+0.28x, n=23, r=0.67, where y is the urinary 1,2-propanediol concentration, in mmol mol creatinine and x is the concentration, in cm3 m-3, of 1-methoxy-2-propanol (90.2%),  1-ethoxy-2-propyl acetate (5.8%), PMA (2.1%) and 1-ethoxy-2-propanol  (1.9%) in the air).

In conclusion, biological monitoring of 1-alkoxy-propanol exposure is possible by urinalysis for its metabolite 1,2-propanediol. At very low occupational exposure levels, the results may be confounded by background excretion of 1,2-propanediol originating from e.g., consumer cosmetics.