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Exposure related observations in humans: other data

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Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1996-1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: There are no guidelines for this type of occupational exposure study and there is sufficient information to permit a meaningful evalaution of study results
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Biological monitoring of occupational exposure to 1-methoxy-2- propanol
Author:
Laitinen J. et al
Year:
1997
Bibliographic source:
Journal of Chromatography B, 694 (1), (1997) 93-98

Materials and methods

Type of study / information:
Type of experience: Human
Endpoint addressed:
not applicable
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
At the end of a workweek 23 silkscreen printers gave a urine sample for capillary gas chromatographic analysis for 1,2-propanediol
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methoxy-1-methylethyl acetate
EC Number:
203-603-9
EC Name:
2-methoxy-1-methylethyl acetate
Cas Number:
108-65-6
Molecular formula:
C6H12O3
IUPAC Name:
2-methoxy-1-methylethyl acetate

Method

Ethical approval:
not specified
Details on study design:
The study was conducted at the end of a workweek. Silkscreen printers (n523) inhalation exposure to 1-methoxy-2-propanol, 1-ethoxy-2-propanol and their acetates was measured from the breathing zone during an 8-h workshift. Healthy clerks (n=14) and fire fighter cadets (n=27) served as unexposed controls, and they also gave urine samples on Friday afternoon at the end of the workshift. None of the controls had a health problem. The statistical differences in the excretion between the controls and the exposed subjects were evaluated with the Student t-test.
Exposure assessment:
not specified
Details on exposure:
same as above

Results and discussion

Results:
At the end of a workweek 23 silkscreen printers gave a urine sample for capillary gas chromatographic analysis for 1,2-propanediol. The mean concentration was 2.52 (S.D. 2.01) mmol mol creatinine-1 (median=1.76,  n=23). The urinary excretion of 1,2-propanediol was linearly dependent on  the preceding 1-methoxy-2-propanol exposure measured in the worker's breathing zone (y=0.99+0.28x, n=23, r=0.67, where y is the urinary 1,2-propanediol concentration, in mmol mol creatinine-1 and x is the concentration, in cm3 m-3, of 1-methoxy-2-propanol (90.2%),  1-ethoxy-2-propyl acetate (5.8%), PMA (2.1%) and 1-ethoxy-2-propanol  (1.9%) in the air).

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
In conclusion, biological monitoring of 1-alkoxy-propanol exposure is possible by urinalysis for its metabolite 1,2-propanediol. At very low occupational exposure levels, the results may be confounded by background excretion of 1,2-propanediol originating from e.g., consumer cosmetics.
Executive summary:

At the end of a workweek 23 silkscreen printers gave a urine sample for capillary gas chromatographic analysis for 1,2-propanediol. The mean concentration was 2.52 (S.D. 2.01) mmol mol creatinine-1 (median=1.76,  n=23). The urinary excretion of 1,2 -propanediol was linearly dependent on  the preceding 1-methoxy-2-propanol exposure measured in the worker's breathing zone (y=0.99+0.28x, n=23, r=0.67, where y is the urinary 1,2-propanediol concentration, in mmol mol creatinine and x is the concentration, in cm3 m-3, of 1-methoxy-2-propanol (90.2%),  1-ethoxy-2-propyl acetate (5.8%), PMA (2.1%) and 1-ethoxy-2-propanol  (1.9%) in the air).

In conclusion, biological monitoring of 1-alkoxy-propanol exposure is possible by urinalysis for its metabolite 1,2-propanediol. At very low occupational exposure levels, the results may be confounded by background excretion of 1,2-propanediol originating from e.g., consumer cosmetics.

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