Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

Smyth et al. (1969) reported an acute oral LD50 value of 180 mg/kg for male rats.

Testing concerning acute inhalation toxicity is not meaningful, since sodium nitrite has an extreme high water solubility and leads to oral uptake.

McLean and Mould (1985; cited in the OECD SIDS) reported an acute inhalative LC0 value of 0.0951 mg/l/4 hours for male and female rats. The animals were offered aerosol concentrations of 10 and 100 mg/m3 (nose-only exposure). During exposure signs typically seen in restrained animals were somewhat more severe in treated animals. Methaemoglobin was significantly increased above concurrent control values only in females exposed to 10 mg/m3. However, the increase was judged to be not haematologically significant as the value was within the range seen for control animals of this age. Further there was no significant increase in males. There were no toxicologically significant effects on animals maintained for 14 days post-exposure.

No data/information is available for acute dermal toxicity. Sodium nitrite is not expected to pass the skin.

Justification for classification or non-classification

Sodium nitrite is classified according to Annex I to the Directive 67/548/EEC with T and R 25.

Classification according to GHS criteria = Acute Tox. Cat. 3.