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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Basic information given in tabular form as part of a screening publication and a NTP technical report. No information regarding bacteriotoxicity provided.

Data source

Referenceopen allclose all

Title:
No information
Author:
NTP Technical Report No. TR-495, May 2001
Reference Type:
publication
Title:
Salmonella Mutagenicity Tests: V. Results from the Testing of 311 Chemicals
Author:
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K.
Year:
1992
Bibliographic source:
Environ Mol Mutagen 19, Supplement 21:2-141

Materials and methods

Principles of method if other than guideline:
according to Zeiger et al. 1992, Environ. Mol. Mutagen. 19 (suppl. 21), 2-141
GLP compliance:
yes
Remarks:
testing lab.
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium nitrite
EC Number:
231-555-9
EC Name:
Sodium nitrite
Cas Number:
7632-00-0
Molecular formula:
HNO2.Na
IUPAC Name:
sodium nitrite
Details on test material:
sodium nitrite, purity: 99%

Method

Target gene:
S. typhimurium
Species / strain
Species / strain / cell type:
other: Salmonella typhimurium TA98, TA100
Metabolic activation:
with and without
Metabolic activation system:
rat liver S-9 mix
Test concentrations with justification for top dose:
0, 100, 333, 1000, 1666, 3333, 6666, and 10000 µg/plate

Results and discussion

Test results
Metabolic activation:
with and without
Genotoxicity:
positive
Additional information on results:
Sodium nitrite was mutagenic in Salmonella typhimurium strain TA100, with and without Aroclor 1254-induced hamster and rat liver S9 enzymes; no mutagenicity was observed in strain TA98.
Remarks on result:
other: other: TA98, TA100
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

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