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EC number: 231-555-9 | CAS number: 7632-00-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Basic information given in tabular form as part of a screening publication and a NTP technical report. No information regarding bacteriotoxicity provided.
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- NTP Technical Report No. TR-495, May 2001
- Reference Type:
- publication
- Title:
- Salmonella Mutagenicity Tests: V. Results from the Testing of 311 Chemicals
- Author:
- Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K.
- Year:
- 1 992
- Bibliographic source:
- Environ Mol Mutagen 19, Supplement 21:2-141
Materials and methods
- Principles of method if other than guideline:
- according to Zeiger et al. 1992, Environ. Mol. Mutagen. 19 (suppl. 21), 2-141
- GLP compliance:
- yes
- Remarks:
- testing lab.
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium nitrite
- EC Number:
- 231-555-9
- EC Name:
- Sodium nitrite
- Cas Number:
- 7632-00-0
- Molecular formula:
- HNO2.Na
- IUPAC Name:
- sodium nitrate
- Details on test material:
- sodium nitrite, purity: 99%
Constituent 1
Method
- Target gene:
- S. typhimurium
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA98, TA100
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver S-9 mix
- Test concentrations with justification for top dose:
- 0, 100, 333, 1000, 1666, 3333, 6666, and 10000 µg/plate
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Additional information on results:
- Sodium nitrite was mutagenic in Salmonella typhimurium strain TA100, with and without Aroclor 1254-induced hamster and rat liver S9 enzymes; no mutagenicity was observed in strain TA98.
- Remarks on result:
- other: other: TA98, TA100
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
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