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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes
Remarks:
according to SIDS

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium nitrite
EC Number:
231-555-9
EC Name:
Sodium nitrite
Cas Number:
7632-00-0
Molecular formula:
HNO2.Na
IUPAC Name:
sodium nitrite
Details on test material:
sodium nitrite

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Controls:
not specified
Amount / concentration applied:
Approximately 500 mg of sodium nitrite
Duration of treatment / exposure:
4 hour(s)
Observation period:
3 days
Number of animals:
6
Details on study design:
The animals were examined one hour, one, two and three days after removal of the chemical.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1 d
Score:
0
Reversibility:
fully reversible
Irritant / corrosive response data:
Some slight irritation was observed one hour after removal of the substance, but all signs had disappeared by the one day observation and the substance is not considered to be a skin irritant.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information

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