Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

 96hr LC50 of >0.26 mg/L  for Leusiscus idus(Hϋls 1993) 
Fundulus heteroclitusto 96 hr LC50 of 0.28 mg octylphenol/L (2 week old larvae)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.26 mg/L

Marine water fish

Marine water fish
Effect concentration:
0.285 mg/L

Additional information

 A review of toxicity test results with short-term octylphenol exposure to fish resulted in three reliable 96 hr studies that included two freshwater and one saltwater species. Test endpoints were based on survival of exposure and test results were reported as LC50concentrations. Freshwater fish results included a LC50of 0.26 mg octylphenol/L forLeusiscus idus(Hϋls 1993) and LC50of >0.1 for Onchorhynchus mykiss (Safepharm 1991). Kelly et al., (2000) exposed four different early life stages (embryo, newly hatched, 2 week old larvae, and 4 week old larvae) of Fundulus heteroclitusto octylphenol and reported a range of LC50concentrations from 0.28 mg octylphenol/L (2 week old larvae) to 3.86 mg octylphenol/L (embryo).  Kelly et al., (2000) results show decreasing sensitivity of life stages for Fundulus heteroclitus to be 2 week old larve > newly hatches larvae > 4 week old larvae > embryo.  

 

The Hϋls (1993) study was selected as key studies because it waswell documented and provided standard survival endpoints for the freshwater test species. The supporting Safepharm (1991) study provides similar documentation, however it is only a screening study, therefore is not selected as a key study. The Kelly et al, (2000) study results provide a range of LC50concentrations for the more sensitive life stages of Fundulus heteroclitus that agree well with the findings of the key study by Hϋls 1993.

 

Categories Display