Registration Dossier
Registration Dossier
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EC number: 205-426-2 | CAS number: 140-66-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A one hour exposure to adult albino rats tested as 45% W/V in isopropyl myristate.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-(1,1,3,3-tetramethylbutyl)phenol
- EC Number:
- 205-426-2
- EC Name:
- 4-(1,1,3,3-tetramethylbutyl)phenol
- Cas Number:
- 140-66-9
- Molecular formula:
- C14H22O
- IUPAC Name:
- 4-(2,4,4-trimethylpentan-2-yl)phenol
- Details on test material:
- - Name of test material (as cited in study report): octylphenol
- Substance type: white colour
- Physical state: granular form
- Composition of test material, percentage of components: phenol <1%, p-octylphenol 89%, o-octylphenol 2%, dioctylphenol 5%, other isomers 3%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino rats
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: 45% W/V solution in isopropyl myristate
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 116 mg/L
- No. of animals per sex per dose:
- 6 in total (no data on sex)
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC100
- Effect level:
- 116 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: 6 of 6 animals died on day 1
Any other information on results incl. tables
Observations: respiratory distress
Gross autopsy: pulmonary hemorrhage
Applicant's summary and conclusion
- Interpretation of results:
- other: information not appropriate to classify the substance
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- 6 out of 6 animals died on day 1 after exposure to 116 mg/l p-(1,1,3,3-Tetramethylbutyl)-phenol. The concentraton is to high to derive a LD50.
- Executive summary:
In an acute inhalation toxicity study, a group of 6 adult albino rats were exposed by inhalation to p-octylphenol (89%) in isopropyl myristate for 1 hour at a concentration of 116 mg/L. All 6 animals died on day.
LC100 = 116 mg/L
Classification of p-(1,1,3,3 -Tetramethylbutyl)-phenol is not possible on based on this study.
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