Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

All induction sites of test and control animals treated with FCA showed intense erythema, swelling and necrosis. Treatment with 1% test substance in corn oil induced distinct erythema and swelling. Corn oil showed slight erythema and swelling. After patch test all induction sites with FCA showed bloody inflammations. 24 hours after patch removal distinct erythema and swelling occurred on the application sites and at the shoulder area (test animals). All injection sites showed incrustations (test and control animals).

Distinct local effects are caused by the irritating properties of the substance. (1,1,3,3 -Tetramethylbutyl)phenol is not considered a dermal sensitizer based on this OECD 406 guideline study.

Migrated from Short description of key information:
The test substance shows no sensitizing potential in a guinea pig maximization test (OECD 406) after intradermal induction with 1% (1,1,3,3 -Tetramethylbutyl)phenol and challenge with 20/50% NP after 7 and 14 days.

Justification for classification or non-classification

(1,1,3,3 -Tetramethylbutyl)phenol does not show sensitizing potential in an OECD 406 guideline study.