Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics
Data waiving:
other justification
Justification for data waiving:

Data source

Reference Type:
Bromine Poison Information Monograph 080
International Programme on Chemical Safety
Bibliographic source:

Materials and methods

Results and discussion

Applicant's summary and conclusion

Executive summary:

The reactivity of bromine in biological systems makes it difficult to study the pharmacokinetics and to separate the effects of bromine from those of the bromine compounds and metabolites that are formed on contact with moisture in mucous membranes and with tissues of the respiratory and gastrointestinal system. Due to its reactivity, bromine does not persist as an element in living tissue, but quickly forms bromide. In this form, it may be deposited in the tissues, displacing other halogens (Sticht and Kaferstein, 1988). Bromide pharmacokinetics are well known from use of bromides as therapeutics. Biological half-life for bromide through ingestion is 12 to 30 days.