Registration Dossier
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EC number: 219-785-8 | CAS number: 2530-85-0
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
- highly water-soluble (>10^6 mg/l)
- low bioavailability (based on log Kow -0.9).
- several short-term aquatic toxicity studies are available indicating no effects up to 1000 mg/l except for an algal NOEC of 322 mg/l when expressed in terms of the silanol hydrolysis product.
No sediment toxicity data are available with 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0). Testing for toxicity to sediment organisms is not considered necessary because:
Due to the rapid hydrolysis of the substance, the chemical safely assessment is based on the silanol hydrolysis product 3-(trihydroxysilyl)propyl methacrylate.
In accordance with REACH Annex XI, there is no need to further investigate the effects of this substance in a toxicity to sediment organisms study because there are sufficient data to derive a (qualitative) risk assessment based on the available data. The qualitative chemical safety assessment is based on the silanol hydrolysis product 3-(trihydroxysilyl)propyl methacrylate, which has the following properties:
Based on the short-term aquatic data set, the most sensitive trophic level is algae, which is also considered a long-term study for the endpoint.
Therefore the occurrence of toxic effects in the sediment comparment that were not expressed in the existing short-term aquatic studies would be considered unlikely.
Overall it is concluded that the chemical safety assessment does not indicate the need for further in vivo testing.
Refer to the discussion in the Section 6 endpoint summary (Section 7.0 of CSR) for further discussion of the approach to chemical safety assessment for the registered substance.
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