Registration Dossier

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
extended one-generation reproductive toxicity - basic test design (Cohorts 1A, and 1B without extension)
Data waiving:
other justification
Justification for data waiving:
other:

Data source

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD TG 443 (extended one generation reproductive toxicity study). The information currently available from repeat dose and developmental toxicity does not suggest need for addition of cohort 3.

Test material

Constituent 1
Chemical structure
Reference substance name:
3-trimethoxysilylpropyl methacrylate
EC Number:
219-785-8
EC Name:
3-trimethoxysilylpropyl methacrylate
Cas Number:
2530-85-0
Molecular formula:
C10H20O5Si
IUPAC Name:
3-(trimethoxysilyl)propyl 2-methylprop-2-enoate
Test material form:
liquid

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion