Registration Dossier
Registration Dossier
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EC number: 200-835-2 | CAS number: 75-05-8
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited information available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Environmental Health Criteria for Acetonitrile. Unedited 1st draft. Internal Technical Report
- Author:
- IPCS
- Year:
- 1 992
- Bibliographic source:
- International Programme for Chemical Safety. WHO, Geneva, Switzerland PCS/EHE/92.12.
- Reference Type:
- publication
- Title:
- Further studies on the etiology of goitre with particular reference to the action of cyanides.
- Author:
- Marine, D. et al.
- Year:
- 1 932
- Bibliographic source:
- Proc. Soc. exp. Biol. Med. 29: 772-775 (cited in IPCS, 1992).
- Reference Type:
- publication
- Title:
- Production of goitre and exophthalmos in rabbits by administration of cyanide.
- Author:
- Marine, D. et al.
- Year:
- 1 932
- Bibliographic source:
- Proc. Soc. exp. Biol. Med. 29: 822-823 (cited in IPCS, 1992).
- Reference Type:
- publication
- Title:
- Production of thyroid hyperplasia in rats and mice by administration of methyl cyanide.
- Author:
- Spence, A.W. and Marine, D.
- Year:
- 1 932
- Bibliographic source:
- Proc. Soc. exp. Biol. Med. 29: 967-968 (cited in IPCS, 1992).
Materials and methods
- Principles of method if other than guideline:
- Subchronic subcutaneous toxicity
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetonitrile
- EC Number:
- 200-835-2
- EC Name:
- Acetonitrile
- Cas Number:
- 75-05-8
- Molecular formula:
- C2H3N
- IUPAC Name:
- acetonitrile
- Details on test material:
- Acetonitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.02, 0.04, 0.08 ml/animal (ca. 45-181 mg/kg bw/d)
- Details on study design:
- Post-exposure period: none
Results and discussion
Effect levels
- Basis for effect level:
- other: Thyroid hyperplasia developed in all groups in a dose-dependant manner
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Thyroid hyperplasia developed in all groups in a dose-dependant manner. At ca. 339 mg/kg there were still no overt effects (Spence and Marine, 1932).
Applicant's summary and conclusion
- Executive summary:
Spence and Marine (1932) reported thyroid hyperplasia in rats administered acetonitrile sc daily for 28 days at doses up to 0.08 mL. These investigators also reported similar thyroid effects in mice and rabbit, with rabbits being most susceptible.
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