Registration Dossier

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2000

Materials and methods

Test material

Constituent 1
Reference substance name:
Hydrogen sulphide
EC Number:
231-977-3
EC Name:
Hydrogen sulphide
Cas Number:
7783-06-4
IUPAC Name:
hydrogen sulfide

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
nose/head only
Vehicle:
air
Details on inhalation exposure:
see 7.2.2
Details on analytical verification of doses or concentrations:
see 7.2.2
Duration of treatment / exposure:
6 hour per day/70 days
Doses / concentrations
Remarks:
Doses / Concentrations:
10-80 ppm
Basis:
analytical conc.
Details on study design:
see 7.2.2

Examinations

Observations and examinations performed and frequency:
In this study 10-week-old male CD rats were subchronically exposed to relatively low concentrations of H2S. The exposure-related lesions in the nasal cavity were evaluated. Rats (n = 12/group) were exposed via inhalation to 0, 10, 30, or 80 ppm H2S 6 h/d and 7 d/wk for 10 weeks. Following exposure to 30 and 80 ppm H2S, a significant increase in nasal lesions limited to the olfactory mucosa was observed.

The lesions, which consisted of olfactory neuron loss and basal cell hyperplasia, were multifocal, bilaterally symmetrical, and had a characteristic rostrocaudal distribution pattern. Regions of the nasal cavity affected included the dorsal medial meatus and the dorsal and medial portions of the ethmoid recess.

Results and discussion

Effect levels

Dose descriptor:
NOAEC
Effect level:
> 10 ppm
Based on:
test mat.
Sex:
male
Basis for effect level:
other: The no observed adverse effect level for olfactory lesions in this study was 10 ppm. These findings suggest that subchronic inhalation exposure to a relatively low level of H2S (30 ppm) can result in olfactory toxicity in rats.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion