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EC number: 231-722-6
CAS number: 7704-34-9
The substance appeared to be irritating, but not corrosive, to the skin; while the test substance is not irritating to the eyes.
Sulfur was examined for acute dermal
irritating/corrosive properties in an experiment with six albino NZW
rabbits, in compliance with OECD guideline 404 and under GLP (TNO,
1994). The test material (0.5 g) was mixed with vaselinum album (0.5 g)
and applied under semi-occlusive conditions for 4 hours. Skin irritation
scores were recorded using Draize criteria at 1, 24, 48 and 72 hours and
at 7 days after removal of the test material. Irritation was initially
absent, however 24 hr after patch removal moderate to severe erythema
(grade 3) and slight oedema (grade 2) had developed in all animals, and
was decreased only slightly at the 48 hr and 72 hr observation periods.
Mean erythema and oedema scores of 2.67 and 1.57, respectively, were
calculated for all animals taking into account responses at 24, 48 and
72 hr, however all skin effects had resolved completely by day 7. On the
basis of these results, it is concluded that sulfur is irritating, but
not corrosive, to rabbit skin.
In a study in compliance with OECD guideline
405 eye irritation study (Rallis Research Centre, 2005), 84 mg
(equivalent to 0.1 ml) of sulfur dust was instilled into the
conjunctival sac of the left eye of three male NZW rabbits. The degree
of irritation/corrosion was evaluated and scored at 1, 24, 48 and 72
hours post-instillation. The mean (24, 48 and 72 hrs) conjunctivae and
chemosis scores were 0.44 and 0.28, respectively (the effects were fully
reversible within 72 hours). Discharge (score 1 to 2) was observed at 1,
24 and 48 hours post instillation. There was no corneal and iris
In a second study in compliance with OECD
guideline 405 and under GLP sulfur was examined for acute eye
irritation/corrosive properties in an experiment with six albino NZW
rabbits (TNO 1994). An amount of 0.1 g of the test substance was
instilled in the conjunctival cul-de-sac of the right eye of six
rabbits. The reactions of the test eyes were judged at 1, 24, 48 and 72
hours and at 7 days after treatment. The mean (24, 48 and 72 hours)
cornea, iris, conjunctivae and chemosis scores were 0, 0, 0.61 and 0.06,
respectively. At 72 hours after treatment, the eye effects had cleared
in five rabbits, whereas the eye effects had cleared at 7 days in the
Justification for selection of skin irritation / corrosion endpoint:
Only available study.
Justification for selection of eye irritation endpoint:
One of two available studies.
Effects on skin irritation/corrosion: irritating
Based on the available
data, sulfur is classified for skin irritation (H315) In
accordance with the EU CLP Regulation (EC No. 1272/2008).
irritation, based on the results of the available studies, sulfur does
not need to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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