Calcium 4-chloro-2-(5-hydroxy-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylazo)-5-methylbenzenesulfonate

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

other: ETAD Analytical Expert Group

Version / remarks:

method for substances with very low solubility in both, water and n-octanol

Principles of method if other than guideline:

Based on the determined solubilities in water and in n-octanol the partition coefficient was estimated. Instead of saturated solvent
systems pure solvents were used.

Type of method:

estimation method (solubility ratio)

Partition coefficient type:

octanol-water

Type:

log Pow

Partition coefficient:

-2.6

Temp.:

24 °C

pH:

ca. 7

Type:

Pow

Partition coefficient:

0.003

Temp.:

24 °C

pH:

ca. 7

Solubility of the test substance in n-octanol: 0.094 mg/l

Water solubility of the test substance : 35.4 mg/l

P_ow = 0.0026

log P_ow = - 2.6

Cross-reference 2

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

similar to OECD 105, test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

modified taking into account the low water solubility of the test substance

Principles of method if other than guideline:

The water solubilty is determined with an analytical method that was agreed upon at the Analytical Experts Meeting of ETAD (Basel) on 12 January 2005 (ETAD: The Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers).

Type of method:

flask method

Water solubility:

35.4 mg/L

Temp.:

24 °C

pH:

ca. 7

_{The solubility of the test substance in water at ambient temperature, determined under the conditions as mentioned above, is 35.4 mg/L (mean, n = 3, sigma = 0.5).}

Table 1: Individual results

	Absorption (d = 1 cm) Dilution 1:10	mg/L
a1	0.1659	35.0
a2	0.1673	35.5
a3	0.1702	35.9

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2007

Report date:

2007

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Analytical Expert Group ETAD

Principles of method if other than guideline:

The method for the determination and analytical investigation is according to the method that was agreed upon at the "Analytical Experts Meeting" of ETAD (Basel) on January 12, 2005.

Test material

Test material information

Constituent 1

Test material form:

solid: bulk

Results and discussion

Solubility in organic solvents / fat solubility

Medium:

n-octanol

Solubility:

94 µg/L

Temp.:

24 °C

Test substance stable:

yes