Calcium 4-chloro-2-(5-hydroxy-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylazo)-5-methylbenzenesulfonate

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

similar to OECD 105, test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

other: ETAD Analytical Expert Group

Version / remarks:

method for substances with very low solubility in both, water and n-octanol

Principles of method if other than guideline:

Based on the determined solubilities in water and in n-octanol the partition coefficient was estimated. Instead of saturated solvent
systems pure solvents were used.

Type of method:

estimation method (solubility ratio)

Partition coefficient type:

octanol-water

Type:

log Pow

Partition coefficient:

-2.6

Temp.:

24 °C

pH:

ca. 7

Type:

Pow

Partition coefficient:

0.003

Temp.:

24 °C

pH:

ca. 7

Solubility of the test substance in n-octanol: 0.094 mg/l

Water solubility of the test substance : 35.4 mg/l

P_ow = 0.0026

log P_ow = - 2.6

Cross-reference 2

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

other: Analytical Expert Group ETAD

Principles of method if other than guideline:

The method for the determination and analytical investigation is according to the method that was agreed upon at the "Analytical Experts Meeting" of ETAD (Basel) on January 12, 2005.

Medium:

n-octanol

Solubility:

94 µg/L

Temp.:

24 °C

Test substance stable:

yes

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2007

Report date:

2007

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

modified taking into account the low water solubility of the test substance

Principles of method if other than guideline:

The water solubilty is determined with an analytical method that was agreed upon at the Analytical Experts Meeting of ETAD (Basel) on 12 January 2005 (ETAD: The Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers).

Type of method:

flask method

Test material

Test material information

Constituent 1

Test material form:

solid: bulk

Results and discussion

Water solubility

Water solubility:

35.4 mg/L

Temp.:

24 °C

pH:

ca. 7

Any other information on results incl. tables

_{The solubility of the test substance in water at ambient temperature, determined under the conditions as mentioned above, is 35.4 mg/L (mean, n = 3, sigma = 0.5).}

Table 1: Individual results

	Absorption (d = 1 cm) Dilution 1:10	mg/L
a1	0.1659	35.0
a2	0.1673	35.5
a3	0.1702	35.9

Applicant's summary and conclusion

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L)