Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Pre-1991
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1991

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Specific details on test material used for the study:
Cyanoguanidine (purity 99. 9 % ) from Sanwa Chemical Co., Ltd

Test animals

Species:
rat
Strain:
Fischer 344/DuCrj
Sex:
female
Details on test animals or test system and environmental conditions:
Five 9-week old female F344 / DuCrj rats (SPF Japan Charles River Co. ) were fasted for 4 hours before the administration of the test material.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
The test substance was dispersed in distilled water and a 20 or 30 g / kg body weight dose was orally administered once.
Doses:
20 and 30 g / kg body weight
No. of animals per sex per dose:
5 female

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
> 30 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion