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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1998
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
publication
Title:
Dicyanodiamide
Author:
DFG, Deutsche Forschungsgemeinschaft
Year:
2007
Bibliographic source:
The MAK-Collection PartI: MAK Value Documentations, Vol. 24

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Not specified in the assessment.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyanoguanidine
EC Number:
207-312-8
EC Name:
Cyanoguanidine
Cas Number:
461-58-5
Molecular formula:
C2H4N4
IUPAC Name:
1-cyanoguanidine
Test material form:
solid: crystalline

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Vehicle:
other: 3% gum arabic solution
Details on oral exposure:
In the diet in concentrations of 0, 12500, 25000, 50000 and 100000 mg/kg diet corresponding to about 0, 570, 1250, 2600 and 5800 mg/kg body weight per day for males and 0, 700, 1500, 3000 and 6800 mg/kg body weight per day for females based on body weight
Duration of treatment / exposure:
13 weeks
Frequency of treatment:
Daily
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Mortality:
no mortality observed
Body weight and weight changes:
effects observed, treatment-related
Description (incidence and severity):
At 12500 mg/kg diet and above.
Food consumption and compound intake (if feeding study):
effects observed, treatment-related
Description (incidence and severity):
At 12500 mg/kg diet and above.
Food efficiency:
effects observed, treatment-related
Description (incidence and severity):
At 12500 mg/kg diet and above.
Haematological findings:
effects observed, treatment-related
Description (incidence and severity):
At 12500 mg/kg diet and above.
Clinical biochemistry findings:
effects observed, treatment-related
Description (incidence and severity):
At 12500 mg/kg diet and above.
Gross pathological findings:
effects observed, treatment-related
Description (incidence and severity):
At 12500 mg/kg diet and above.

Effect levels

Key result
Dose descriptor:
NOAEL
Effect level:
570 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
clinical signs

Target system / organ toxicity

Key result
Critical effects observed:
yes
Lowest effective dose / conc.:
570 mg/kg bw/day (nominal)
System:
haematopoietic
Organ:
blood
Treatment related:
yes
Dose response relationship:
yes
Relevant for humans:
not specified

Applicant's summary and conclusion

Conclusions:
The NOAEL for the test substance in a 90-day feeding study in rats was 570 mg/kg bw/day.