Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-312-8 | CAS number: 461-58-5
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Dicyanodiamide
- Author:
- DFG, Deutsche Forschungsgemeinschaft
- Year:
- 2 007
- Bibliographic source:
- The MAK-Collection PartI: MAK Value Documentations, Vol. 24
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Not specified in the assessment.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Cyanoguanidine
- EC Number:
- 207-312-8
- EC Name:
- Cyanoguanidine
- Cas Number:
- 461-58-5
- Molecular formula:
- C2H4N4
- IUPAC Name:
- 1-cyanoguanidine
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: 3% gum arabic solution
- Details on oral exposure:
- In the diet in concentrations of 0, 12500, 25000, 50000 and 100000 mg/kg diet corresponding to about 0, 570, 1250, 2600 and 5800 mg/kg body weight per day for males and 0, 700, 1500, 3000 and 6800 mg/kg body weight per day for females based on body weight
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- Daily
- Control animals:
- not specified
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- At 12500 mg/kg diet and above.
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- At 12500 mg/kg diet and above.
- Food efficiency:
- effects observed, treatment-related
- Description (incidence and severity):
- At 12500 mg/kg diet and above.
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- At 12500 mg/kg diet and above.
- Clinical biochemistry findings:
- effects observed, treatment-related
- Description (incidence and severity):
- At 12500 mg/kg diet and above.
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- At 12500 mg/kg diet and above.
Effect levels
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 570 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
Target system / organ toxicity
- Key result
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 570 mg/kg bw/day (nominal)
- System:
- haematopoietic
- Organ:
- blood
- Treatment related:
- yes
- Dose response relationship:
- yes
- Relevant for humans:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The NOAEL for the test substance in a 90-day feeding study in rats was 570 mg/kg bw/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
