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EC number: 203-468-6 | CAS number: 107-15-3 EDA
LD50/LC50 values are based on animal test data for acute toxicity.
Mean weight (g):
Clinical signs: symptoms occured in the indicated time:
min: minute; h: hour; d: day
There is indication that the test substance causes local irritation to exposed tissues.
In an acute toxicity test on rats, test groups consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior treatment and thereafter, day 3, day 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. An LD50 value of 866 mg/kg was estimated on the basis of the observed mortalities.
Rats were exposed to metered concentrations of EDA vapor for 8h. Six male rats per dose group were exposed to 2000 and 4000 ppm EDA vapour for 8h. Mortality of rats was observed for a 14 day period. No deaths were observed in the 2000 ppm dose group, and 100% mortality was observed in the 4000 ppm dose group. Taking the geometric mean as the LC50 value, and calculating back to 4h exposure gives an LC50 of 14.7 mg/l
Necrosis of the skin, congestion of the lungs and damage to the abdominal organs was noted on autopsy.
Rabbits were exposed to concentrated ethylene diamine (76%) and a 10% dilution in water under occlusive coverage for 24 h. With the concentrated substance, severe skin damage occurred. Congestion of the lungs and damage to the abdominal organs was noted on autopsy. LD50 was 560 mg/kg bw. For the diluted samples LD50 was approximately 1520 mg/kg bw.
In an acute inhalation toxicity test, an 8h LC50 value was calculated as the geometric mean of LC0 and LC100 values. Back calculation using Habers law, C*t =k, gives the 4h LC50 value of 14.7 mg/L. This is supported by another study, with an 8h LC0 value of 11 mg/L.
A classification for Acute oral toxicity cat IV, acute dermal toxicity catIII and acute inhalation toxicity cat IV is proposed.
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