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EC number: 203-560-6 | CAS number: 108-20-3
Short description of key information on bioaccumulation potential result:
In accordance with Regulation (EC) No 1907/2006 Annex VIII section 8.8.1, a toxicokinetics study is not required as assessment of the toxicokinetic behaviour of the substance has been derived from the relevant available information. This assessment is located within the endpoint summary for toxicokinetics, metabolism and distribution.
The low molecular weight (102.17 g/mol), log Pow, physical state, moderate vapour pressure (19.9 kPa at 25°C), and high water solubility of di-isopropyl ether (DIPE) favour its absorption via various routes of exposure (i.e., oral, dermal, and respiratory). Data regarding the hydrolysis and metabolism of DIPE are limited, although it has been reported that the compound is not metabolised in vivo . The absorption of DIPE and its distribution to the liver following respiratory exposure in rats was demonstrated by the results of a toxicokinetic study by Linde and Berman (1971) . In this study, it was demonstrated that exposure to DIPE increased the rate of hepatic metabolism of hexobarbitol. These results imply that upon systemic absorption, DIPE is distributed to the liver, where it likely causes increased production, stabilization, and/or activity of the enzymes responsible for the metabolism of hexobarbitol. However, the results of this study did not provide any information regarding the metabolism or excretion of DIPE. The absorption of DIPE following oral exposure was supported by the results of 2 studies, in which mortality or increased incidence of malignant tumours, but no tissue-specific systemic effects, were reported [8, 11]. Since no compound-related clinical effects were reported, no information regarding distribution, metabolism, or excretion could be deduced from the results of these studies. No compound-related clinical or biochemical effects were observed in the available inhalation neurotoxicity and dermal toxicity studies [9, 12]. Although the lack of observed effects suggests that DIPE was not absorbed, it does not preclude the absorption of some of the applied dose.
The rapid intoxication (i.e., salivation, lack of coordination, excitation, shivering, slowed respiration, and depressed behaviour) and eventual respiratory depression observed following oral and respiratory exposure in monkeys, rabbits, and guinea pigs demonstrates that DIPE is absorbed, and that it crosses the blood-brain barrier [9, 10]. Pathological changes to brain, heart, liver, and kidney tissue were observed following oral and respiratory exposure to DIPE in rats, monkeys, rabbits, and guinea pigs, suggesting that DIPE is widely distributed upon systemic absorption [9, 10]. Whether DIPE is metabolized and/or excreted via the liver and kidneys could not be deduced based on the results of these studies. In the study by Machle et al. (1938) , animals administered the lowest dose level associated with reported effects in all species tested (i.e., 30000 ppm DIPE) recovered from the observed anaesthesia, cyanosis, and respiratory depression within 20 minutes of cessation of exposure. As excretion and metabolism were not assessed in this study, the observation of rapid recovery suggests (but does not demonstrate) that DIPE may be rapidly eliminated, and may therefore be unlikely to bioaccumulate.
Dose-related fetal effects (i.e., increased incidence of rudimentary and short 14th ribs) were observed following respiratory exposure of pregnant rats to DIPE during fetal organogenesis, but the authors argued that this was not indicative of adverse effects on development . Since evidence of systemic maternal toxicity was not observed, the results of this study suggest that DIPE likely crosses the placental barrier in rats.
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 Szymanska JA, Bruchajzer E (2007) Podstawy i Metody Oceny Srodowiska Pracy [Diisopropyl ether. Documentation of permissible occupational exposure values]. Uniw Med Łódź 23(1):39-55. Publisher: Centralny Instytut Ochrony Pracy, CODEN: PMOSC3 ISSN: 1231-868X. [Journal written in Polish.] CAN 147:306689 AN 2007:659757 CAPLUS
 Kimura ET, Ebert DM, Dodge PW (1971) Acute toxicity and limits of solvents residue for sixteen organic solvents. Toxicol Appl Pharm, 19:699-704
 Machle W, Scott EW, Treon J (1938) The physiological response to isopropyl ether and to a mixture of isopropyl ether and gasoline. J Hyg Toxicol, 21:72-96
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 Belpoggi F, Soffritti M, Minardi F, Bua L, Cattin E, Maltoni C (2002) Results of long-term carcinogenicity bioassays on tert-amyl-methyl-ether (TAME) and di-isopropyl-ether (DIPE) in rats. Ann NY Acad Sci., 982:70-86
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