Registration Dossier
Registration Dossier
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EC number: 700-487-6 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 = 2.02 mg/L (OECD Guideline 203, static renewal; GLP, RL1)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.02 mg/L
Additional information
In a 96 h acute toxicity study according to OECD guideline 203, adopted 17 July 1992, Zebrafish (Danio rerio) were exposed to Epoxy half acrylate (100% a.i.) at nominal concentrations of 0, 0.625, 1.25, 2.50, 5.00 and 10.0 mg/L, corresponding to geometric mean weighted loading levels of 0, 0.239, 0.599, 1.25, 3.27 and 4.98 mg/L under semi-static conditions with daily renewal. 7 test organisms were exposed to each loading level and the control.
The concentrations of the analytes of the test item were analytically verified by LC-MS/MS from freshly prepared test media after 0 and 72 hours and corresponding 24 h aged test media after 24 and 96 hours of all concentration levels and the control.
Effect levels are given based on overall geometric mean weighted test item loadings.
100% mortality was observed at 4.98 mg/L. Sublethal effects (hyperventilation and missing escape reflex) were observed at a concentration of 3.27 mg/L. No mortality or sublethal effects were present at up to 1.25 mg/L.
The 96 h LC50 was 2.02 mg/L (95% CL: 1.25-3.27 mg/L).
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