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EC number: 231-959-5
CAS number: 7782-50-5
To summarise, measurements of the single breath-bolus penetration distribution of Cl2 during nasal as well as oral quiet breathing in five men and five women indicated that > 95 % of inspired Cl2 was absorbed in the upper airways of all subjects, whereas the dose delivered to the respiratory air spaces was negligible. Although there were no statistically significant gender differences in the results, individual values of Ka(oral) were inversely correlated with individual values of VOR. Representative overall mass transfer coefficients estimated in the nose were in good agreement with gas-phase mass transfer coefficients calculated from established correlations. This suggested that diffusional resistance in the nasal mucosa was negligible relative to diffusional resistance in the respired gas. Both the high absorptivity of Cl2 in the upper airways and the domination of the gas-phase diffusion resistance were attributable to the rapid hydrolysis of Cl2in the mucosa.
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