2,4,6-trinitrotoluene

Long-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to fish, other

Remarks:

EPA 821-R-02-012

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Qualifier:

equivalent or similar to guideline

Guideline:

other: Modified U.S. Environmental Protection Agency. 2002. Methods for measuring the acute toxicity of effluents and receiving waters to freshwater and marine organisms, 5th ed. EPA-821-R-02-012. Office of Water, Washington, DC

GLP compliance:

not specified

Test organisms (species):

Pimephales promelas

Test type:

semi-static

Water media type:

freshwater

Total exposure duration:

10 d

Duration:

10 d

Dose descriptor:

LC50

Effect conc.:

2.2 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: 95% CL

LC50 (10 d): > 9.17 — < 10.22 µmol/L test mat. (meas. (geom. mean)) based on: mortality (95% CL)

Description of key information

Median lethal concentration of 9.68 µmol/L (2.20 mg/L; 95% CL, 9.17 -10.22 µmol/L) was calculated in 10 -d experiments.

LC50: 2.20 mg/L