Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Technical Reports
Author:
RCC NOTOX B.V.
Year:
1988
Bibliographic source:
RCC Notox, Technical Report No. 1074; cited in RTECS, 2000

Materials and methods

Principles of method if other than guideline:
Study to assess the acute inhalative toxicity in rats.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Nickel dihydroxide
EC Number:
235-008-5
EC Name:
Nickel dihydroxide
Cas Number:
12054-48-7
Molecular formula:
H2NiO2
IUPAC Name:
nickel(2+) dihydroxide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
1.2 mg/L air
Exp. duration:
4 h
Remarks on result:
other: original data: 1200mg/m3

Applicant's summary and conclusion