Registration Dossier
Registration Dossier
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EC number: 235-008-5 | CAS number: 12054-48-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed data, acceptable for assessment.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test.
- Author:
- De Flora S. et al.
- Year:
- 1 984
- Bibliographic source:
- OECD SIDS-Draft; original source: Mutat. Res., 133, 161-198
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- nickel nitrate
- IUPAC Name:
- nickel nitrate
- Details on test material:
- - Name of test material (as cited in study report): nickel nitrate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA1535, TA100, TA1538, TA98, TA1537, TA97
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- no data
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA1535, TA100, TA1538, TA98, TA1537, TA97
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Negative results were seen in the bacterial reverse mutation assay.
Applicant's summary and conclusion
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