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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-08-11 - 2008-11-07
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge
Radiolabelling:
no
Test temperature:
25 oC
Details on study design: HPLC method:
Column: ZORBAX CN, 5|im, 150 x 4.6 mm

Mobile phase: 550 mL of 0.01 M citrate-buffer pH = 6.0 + 450 ml of methanol
Detection:
210 nm - NaN03
240 nm - the reference substances
214 nm - the test substance
Flow: 1.0 mL/ min

Injection volume: 10 µL
Column temp.: 25°C
Analytical monitoring:
yes
Key result
Type:
log Koc
Value:
1.2
Temp.:
25 °C
Remarks on result:
other: Soil
Key result
Type:
log Koc
Value:
1.2
Temp.:
25 °C
Remarks on result:
other: Sewage sludge
Details on results (HPLC method):
Compound Retention time tK (min)
I II III IV
Test substance 2.337 2.337 2.337 2.338
Transformation products:
not measured

The retention times of the reference compounds

Reference compound

Retention timetn(min)

I

II

III

IV

Acetanilide

2.726

2.725

2.725

2.725

Benzamide

2.375

2.374

2.375

2.375

2-Nitrobenzamide

2.281

2.283

2.283

2.282

Atrazin

3.809

3.808

3.808

3.808

Aniline

2.591

2.593

2.592

2.591

2.5-Dichloroaniline

4.666

4.666

4.665

4.664

Phenyl benzoate

8.145

8.145

8.142

8.138

Retention times of the test substance

Compound

Retention timetn(min)

I

II

III

IV

Test substance

2.337

2.337

2.337

2.338

Validity criteria fulfilled:
yes
Conclusions:
Adsorption coefficient of 3-Methylpyrazol on soil:

log Koc (soil) = 1.2 +/- 0.8 (pH = 6.0; 25°C)

Adsorption coefficient of 3-Methylpyrazol on sewage sludge:

log Koc (sludge) = 1.2 +/- 0.8 (pH = 6.0; 25°C)

The log Koc values lie outside the limits of applicability of used method. Because the determined adsorption coefficients are close to the lower limit of the method, the result may be considered reliable.
Executive summary:

The adsorption coefficient of test substance, 3-Methylpyrazol, on soil and on sewage sludge was estimated. The HPLC method with reference compounds was used. The test was performed according to the Method C.19, Estimation of the adsorption coefficient (Koe) on soil and sewage sludge using high performance liquid chromatography (HPLC), Council Regulation (EC) No 440/2008, Published in O.J.I. 142, 2008.

Adsorption coefficient of 3-Methylpyrazol on soil: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)

Adsorption coefficient of 3-Methylpyrazol on sewage sludge: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)

Description of key information

Adsorption coefficient of 3-Methylpyrazol on soil: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)

Adsorption coefficient of 3-Methylpyrazol on sewage sludge: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)

solids/water coefficient was calculated with EUSES 2.1 = 0.95  m3 x m-3 => log kp solids/water = 0 L/kg for a density of 1

suspended-matter/water coefficient was calculated with EUSES 2.1 = 1.36 m3 x m-3 => log kp suspended-matter/water = 0.13 L/kg for a density of 1

sediment-matter/water coefficient was calculated with EUSES 2.1 = 1.26 m3 x m-3 => log kp suspended-matter/water = 0.1 L/kg for a density of 1

Key value for chemical safety assessment

Koc at 20 °C:
15.8

Other adsorption coefficients

Type:
log Kp (sediment-water)
Value in L/kg:
0.1
at the temperature of:
25 °C

Other adsorption coefficients

Type:
log Kp (suspended matter-water)
Value in L/kg:
0.13
at the temperature of:
25 °C

Additional information

The reported study is GLP compliant and has Klimisch score 1.

Adsorption coefficient of 3-Methylpyrazol on soil: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)

Adsorption coefficient of 3-Methylpyrazol on sewage sludge: log Koc = 1.2 +/- 0.8 (pH = 6.0, 25°C)

[LogKoc: 1.2]

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