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Description of key information

In vivo, isobutyl-R-lacate is rapidly hydrolysed enzymatically. Therefore, the toxicologically relevant compounds following systemic uptake are lactic acid/lactate (low toxicological concern) and isobutanol.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Isobutyl-R-lactate, as all lactate esters, is rapidly hydrolysed in vivo into lactic acid and isobutanol.

Lactic acid is a ubiquitous and essential biological molecule, in humans and other mammals, but also in most if not all vertebrate and invertebrate animals, as well as in many micro-organisms. Therefore the biokinetics, metabolism and distribution of lactic acid have to be considered in the context of its normal biochemistry; lactic acid is of minor toxicological concern given its ubitquitousness and function as a common metabolite.

Isobutanol is an alcohol that is metabolised by the normal alcohol metabolism pathways.