Registration Dossier
Registration Dossier
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EC number: 203-862-8 | CAS number: 111-36-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of n-butylamine, the hydrolysis product of n-butylisocyanate, to Daphnia magna is EC50 > 100 mg/L at 48 h (Pedersen 1998). Butyl isocyanate was shown to completely hydrolyze during the solution step, which took 6 minutes yielding n-butyl amine and 1,3-dibutyl urea as transformation products (Bayer Industry Services, 2005). Compared to the applied concentration of butyl isocyanate, 92 % n-butyl amine and only 8 % of 1,3-dibutyl urea were formed. Thus, n-butyl amine represents the main transformation product. Since the duration of the bio assay is quite greater than the dissipation time of butyl isocyanate, results obtained through the testing of n-butyl amine can be used to assess the risk of butyl isocyanate towards aquatic organisms. Effects of 1,3-dibutyl urea can be neglected due to the low concentration formed.
Key value for chemical safety assessment
Additional information
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