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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

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Description of key information

The acute toxicity of n-butylamine, the hydrolysis product of n-butylisocyanate, to Daphnia magna is EC50 > 100 mg/L at 48 h (Pedersen 1998). Butyl isocyanate was shown to completely hydrolyze during the solution step, which took 6 minutes yielding n-butyl amine and 1,3-dibutyl urea as transformation products (Bayer Industry Services, 2005). Compared to the applied concentration of butyl isocyanate, 92 % n-butyl amine and only 8 % of 1,3-dibutyl urea were formed. Thus, n-butyl amine represents the main transformation product. Since the duration of the bio assay is quite greater than the dissipation time of butyl isocyanate, results obtained through the testing of n-butyl amine can be used to assess the risk of butyl isocyanate towards aquatic organisms. Effects of 1,3-dibutyl urea can be neglected due to the low concentration formed.

Key value for chemical safety assessment

Additional information