Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-862-8 | CAS number: 111-36-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Considerable deficiencies (i.e. one animal per dose, no data on exposure period)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
- Principles of method if other than guideline:
- The compound was applied as a 75% dilution in corn oil to the closely clipped intact skin of a male or female albino rabbit.
A leather collar had previously been placed around the neck of each animal to prevent it from turning its head sufficiently
to get at the sample; observations were made for toxic symptoms and the viscera of those animals that succumbed was
examined macroscopically. Exposure duration: no data; Post observation period: no data - GLP compliance:
- no
- Test type:
- other: no data
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- IUCLID4 Test substance: other TS: n-butyl isocyanate, no data on purity
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- corn oil
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- 1000, 2500, 4000, 5000, 6000, 8000 mg/kg bw
- No. of animals per sex per dose:
- 1
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: skin absorption MLD
- Effect level:
- ca. 6 000 - ca. 8 000 mg/kg bw
- Mortality:
- No mortality <= 6000 mg/kg bw
After the application of 8000 mg/kg bw the animal died overnight. - Clinical signs:
- The animals squealed and jumped around their cages for ten to fifteen minutes at the higher dosage levels (no further information available). Ocular and nasal irritation from the vapors appeared to be a factor in this reaction.
- Body weight:
- no data
- Gross pathology:
- At autopsy the viscera appeared normal by macroscopic examination excepting for pulmonary hyperemia.
- Other findings:
- A decrease in appetite and activity for several days was observed. Muscular coordination was markedly affected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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