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EC number: 203-862-8 | CAS number: 111-36-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Considerable deficiencies (i.e. one animal per dose, no data on exposure period)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
- Principles of method if other than guideline:
- The compound was applied as a 75% dilution in corn oil to the closely clipped intact skin of a male or female albino rabbit.
A leather collar had previously been placed around the neck of each animal to prevent it from turning its head sufficiently
to get at the sample; observations were made for toxic symptoms and the viscera of those animals that succumbed was
examined macroscopically. Exposure duration: no data; Post observation period: no data - GLP compliance:
- no
- Test type:
- other: no data
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- IUCLID4 Test substance: other TS: n-butyl isocyanate, no data on purity
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- corn oil
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- 1000, 2500, 4000, 5000, 6000, 8000 mg/kg bw
- No. of animals per sex per dose:
- 1
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: skin absorption MLD
- Effect level:
- ca. 6 000 - ca. 8 000 mg/kg bw
- Mortality:
- No mortality <= 6000 mg/kg bw
After the application of 8000 mg/kg bw the animal died overnight. - Clinical signs:
- The animals squealed and jumped around their cages for ten to fifteen minutes at the higher dosage levels (no further information available). Ocular and nasal irritation from the vapors appeared to be a factor in this reaction.
- Body weight:
- no data
- Gross pathology:
- At autopsy the viscera appeared normal by macroscopic examination excepting for pulmonary hyperemia.
- Other findings:
- A decrease in appetite and activity for several days was observed. Muscular coordination was markedly affected.
Applicant's summary and conclusion
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