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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1985-05-08 to 1985-05-11
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,2-trifluoroethyl methacrylate
EC Number:
206-525-3
EC Name:
2,2,2-trifluoroethyl methacrylate
Cas Number:
352-87-4
Molecular formula:
C6H7F3O2
IUPAC Name:
2,2,2-trifluoroethyl methacrylate
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): MATRIFE

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.44 -3.01 kg
- Housing: individually in suspended metal cages
- Diet (e.g. ad libitum): standard laboratory diet, ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5±1.5°C
- Humidity (%):50-55%
- Air changes (per hr): approx. 10/h
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
Duration of treatment / exposure:
4 h
Observation period:
72 h
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: 2.5x2.5 cm
- Type of wrap if used: patches were held in place with Sleek adhesive strapping; elasticated corset

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, any residual test material was removed by gently swabbing cotton wool soaked in ether
- Time after start of exposure: 4 h

SCORING SYSTEM: Draize (OECD 404)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: #1, #2, #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal: #1, #2, #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritating effects were noted in any animal during the observation period.

Any other information on results incl. tables

Rabbit number

reaction

1/24/48/72h

1

erythema

0/0/0/0

edema

0/0/0/0

2

erythema

0/0/0/0

edema

0/0/0/0

3

erythema

0/0/0/0

edema

0/0/0/0

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
TFMEA was not irritating to rabbit skin in this study.
Executive summary:

In a primary dermal irritation study according to OECD guideline 404, 3 young adult New Zealand White rabbits were dermally exposed to 0.5 mL of undiluted TFMEA (purity not given in the study report, but according to sponsor >90%) for 4 h hours to 6.25 cm² body surface area. Animals then were observed for 3 days.  Irritation was scored by the method of Draize.

No irritating effects were noted in any animal during the observation period.

In this study, TFMEA is not a dermal irritant.