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Description of key information

Acetate C-8 is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data is from peer reviewed journal
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity test was conducted in rats
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
3000 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available
Preliminary study:
No data available
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % morality was observed
Mortality:
50 % morality was observed in traded rats at 3000 mg/kg
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available
Interpretation of results:
practically nontoxic
Conclusions:
LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.
Executive summary:

In a acute oral toxicity study, rats were treated wtih Acetate C-8 in the contrition of 3000 mg/kg orally. 50 % morality was observed in traded rats at 3000 mg/kg. Therefore, LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
3 000 mg/kg bw
Quality of whole database:
Data is Klimisch 2 and from peer reviewed journal

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer-reviewed jouranl
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Acute dermal toxicity test of Acetate C-8 in rabbits.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available
Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
5000 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available
Preliminary study:
No data available
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No morality was observed
Mortality:
No morality was observed in traded rabbits at 5000 mg/kg
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available
Interpretation of results:
practically nontoxic
Conclusions:
LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.
Executive summary:

In a acute dermal toxicity study, rabbits were treated with Acetate C-8 in the contrition of 5000 mg/kg dermally. No morality was observed in traded rabbits at 5000 mg/kg. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
Data is Klimisch 2 and from peer reviewed journal

Additional information

Acute oral toxicity:

Based on the data available for target Acetate C-8 (CAS no 112-14-1) is summarized below

In study conducted by Baret al(1974), acute oral toxicity was evaluated in rats by using Acetate C-8 in the contrition of 3000 mg/kg orally. 50 % morality was observed in traded rats at 3000 mg/kg. Therefore, LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.

In a study given by Daughtreyet al(1989), acute oral toxicity was evaluated rats by using Octyl Acetate in the concentration of 5000 mg/kg bw orally. 50% mortality was observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be approximately 5000 mg/kg bw when rat were treated with Octyl Acetate orally. 

Based on the prediction done by using QSAR Toolbox 3.4. (2016), acute oral toxicity was estimated in albino female rats by using Octyl Acetate orally. 50 % mortality was observed at 4263.5 mg/kg bw in treated female rats. Therefore, estimated LD50 was considered to be 4263.5 mg/kg bw when albino female rats were treated with Octyl Acetate orally.

Thus, based on the available data for target Acetate C-8 (CAS no 112-14-1) is likely to be non hazardous by oral route of exposure in rats.

Acute dermal toxicity:

Based on the data available for target Acetate C-8 (CAS no 112-14-1) is summarized below

In study conducted by Moreno,et al(1974), acute dermal toxicity was evaluated in rabbits by using Acetate C-8 in the contrition of 5000 mg/kg dermally. No morality was observed in traded rabbits at 5000 mg/kg. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.

In a study given by Daughtreyet al(1989), acute dermal toxicity was evaluated in rabbits by using Octyl Acetate in the concentration of 3000 mg/kg bw dermally. No mortality was observed in treated rabbits at 3000 mg/kg bw. Therefore, LD50 was considered to be > 3000 mg/kg bw when rabbits were treated with Octyl Acetate dermally.

Based on the prediction done by using QSAR Toolbox 3.4. (2016), acute dermal toxicity was estimated in rabbits by using Octyl Acetate dermally. 50 % mortality was observed at 4655 mg/kg bw in treated rabbits. Therefore, estimated LD50 was considered to be 4655mg/kg bw when rabbits were treated with Octyl Acetate dermally.

Thus, based on the available data for target Acetate C-8 (CAS no 112-14-1) is likely to be non hazardous by dermal route of exposure in rabbits.

Justification for selection of acute toxicity – oral endpoint

LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.

Justification for selection of acute toxicity – dermal endpoint

LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.

Justification for classification or non-classification

Based on the available data for target Acetate C-8 (CAS no 112-14-1) is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits..