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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer-reviewed jouranl

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: Acetate C-8
Author:
Moreno
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology. 12, 815, 1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Acute dermal toxicity test of Acetate C-8 in rabbits.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Octyl acetate
EC Number:
203-939-6
EC Name:
Octyl acetate
Cas Number:
112-14-1
Molecular formula:
C10H20O2
IUPAC Name:
octyl acetate
Constituent 2
Reference substance name:
Acetate C-8
IUPAC Name:
Acetate C-8
Details on test material:
- Name of test material (as cited in study report): Acetate C-8
- Molecular formula (if other than submission substance): C10H20O2
- Molecular weight (if other than submission substance): 172.266 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
5000 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No morality was observed
Mortality:
No morality was observed in traded rabbits at 5000 mg/kg
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Conclusions:
LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.
Executive summary:

In a acute dermal toxicity study, rabbits were treated with Acetate C-8 in the contrition of 5000 mg/kg dermally. No morality was observed in traded rabbits at 5000 mg/kg. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.