Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: Acetate C-8
Author:
Bar
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology. 12, 815, 1974

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity test was conducted in rats
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octyl acetate
EC Number:
203-939-6
EC Name:
Octyl acetate
Cas Number:
112-14-1
Molecular formula:
C10H20O2
IUPAC Name:
octyl acetate
Constituent 2
Reference substance name:
Acetate C-8
IUPAC Name:
Acetate C-8
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): Acetate C-8
- Molecular formula (if other than submission substance): C10H20O2
- Molecular weight (if other than submission substance): 172.266 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
3000 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % morality was observed
Mortality:
50 % morality was observed in traded rats at 3000 mg/kg
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Conclusions:
LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.
Executive summary:

In a acute oral toxicity study, rats were treated wtih Acetate C-8 in the contrition of 3000 mg/kg orally. 50 % morality was observed in traded rats at 3000 mg/kg. Therefore, LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.