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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from REAXYS

Data source

Reference
Reference Type:
review article or handbook
Title:
Reaxys ID 1821283
Year:
2011
Bibliographic source:
Reaxys by Elsevier Properties SA;Greim, H.; Ahlers, J; Bias, R.; Broecker, B.; Hollander, H.; et al. ; Chemosphere; vol. 28; nb. 12; (1994); p. 2203 2236,

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Acute oral toxicity of 2-Amino-8-hydroxynaphthalene-6-sulfonic acid in rats.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
EC Number:
202-000-8
EC Name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
Cas Number:
90-51-7
IUPAC Name:
6-amino-4-hydroxynaphthalene-2-sulfonic acid
Constituent 2
Reference substance name:
2-Amino-8-hydroxynaphthalene-6-sulfonic acid
IUPAC Name:
2-Amino-8-hydroxynaphthalene-6-sulfonic acid
Details on test material:
Name:

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: peroral
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No data available
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be > 5000 mg/kg bw when rats were treated with 2-Amino-8-hydroxynaphthalene-6-sulfonic acid orally.
Executive summary:

In a acute oral toxicity study, rats were treated with 2-Amino-8-hydroxynaphthalene-6-sulfonic acid in the concentration of 5000 mg/kg bw orally. No mortality was observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be > 5000 mg/kg bw when rats were treated with 2-Amino-8-hydroxynaphthalene-6-sulfonic acid orally.