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Registration Dossier
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EC number: 202-058-4 | CAS number: 91-30-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from REAXYS
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Reaxys ID 1821283
- Year:
- 2 011
- Bibliographic source:
- Reaxys by Elsevier Properties SA;Greim, H.; Ahlers, J; Bias, R.; Broecker, B.; Hollander, H.; et al. ; Chemosphere; vol. 28; nb. 12; (1994); p. 2203 2236,
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity of 2-Amino-8-hydroxynaphthalene-6-sulfonic acid in rats.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 202-000-8
- EC Name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 90-51-7
- IUPAC Name:
- 6-amino-4-hydroxynaphthalene-2-sulfonic acid
- Reference substance name:
- 2-Amino-8-hydroxynaphthalene-6-sulfonic acid
- IUPAC Name:
- 2-Amino-8-hydroxynaphthalene-6-sulfonic acid
- Details on test material:
- Name:
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: peroral
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be > 5000 mg/kg bw when rats were treated with 2-Amino-8-hydroxynaphthalene-6-sulfonic acid orally.
- Executive summary:
In a acute oral toxicity study, rats were treated with 2-Amino-8-hydroxynaphthalene-6-sulfonic acid in the concentration of 5000 mg/kg bw orally. No mortality was observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be > 5000 mg/kg bw when rats were treated with 2-Amino-8-hydroxynaphthalene-6-sulfonic acid orally.
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